3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER

Base Information

• Chemical Name: 3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER
• CAS No.: 6512-32-9
• Molecular Formula: C11H14 O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• Mol file: 6512-32-9.mol

Synonyms:Aceticacid, (3,5-dimethoxyphenyl)-, methyl ester (7CI,8CI);(3,5-Dimethoxyphenyl)acetic acid methyl ester; Methyl(3,5-dimethoxyphenyl)acetate

Chemical Property of 3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER

Chemical Property:

• Refractive Index: 1.5200 to 1.5240
• Boiling Point: 94°C/0.04mmHg(lit.)
• PSA: 44.76000
• Density: 1.105±0.06 g/cm3(Predicted)
• LogP: 1.41930
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

3,5-DimethoxyphenylaceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER

There total 14 articles about 3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(3,5-dihydroxyphenyl)acetate (4724-10-1) + dimethyl sulfate (77-78-1) → methyl 2-(3,5-dimethoxyphenyl)acetate (6512-32-9)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.bioorg.2021.105305

Reference yield: 100.0%

methanol (67-56-1) + (3,5-dimethoxyphenyl)acetic acid (4670-10-4) → methyl 2-(3,5-dimethoxyphenyl)acetate (6512-32-9)

Guidance literature:

With sulfuric acid; for 4h; Heating;

DOI:10.1002/jhet.5570400317

Reference yield: 100.0%

(3,5-dimethoxyphenyl)acetic acid (4670-10-4) + methyl iodide (74-88-4) → methyl 2-(3,5-dimethoxyphenyl)acetate (6512-32-9)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃;

DOI:10.1002/adsc.201901343

upstream raw materials:

diazomethane

methanol

3,5-dimethoxybenzoic acid

methyl 2-(3,5-dihydroxyphenyl)acetate

Downstream raw materials:

(2-carboxymethyl-4,6-dimethoxy-phenyl)-glyoxylic acid

(2-formyl-3,5-dimethoxy-phenyl)-acetic acid methyl ester

(S)-4-Benzyl-3-[2-(3,5-dimethoxy-phenyl)-acetyl]-oxazolidin-2-one

(S)-3-[(S)-2-Azido-2-(3,5-dimethoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one

Refernces

• 1、 Banoth, Shivalal,Choudhury, Utkal Mani,Marumudi, Kanakaraju,Kunwar, Ajit C.,Mohapatra, Debendra K.. "Concise Total Synthesis of Curvulone B". supporting information. p. 685 - 688. Retrieved 2020/12/07.
• 2、 Mura Reddy, Gudisela,Prasad, K. R. S.,Reddy, G. Nagendra,Sridhar, Gattu. "Synthesis of (+)-xestodecalactone A". supporting information. . Retrieved 2021/06/27.