5-CHLOROGRAMINE

Base Information

• Chemical Name: 5-CHLOROGRAMINE
• CAS No.: 830-94-4
• Molecular Formula: C11H13ClN2
• Molecular Weight: 208.69
• Hs Code.: 2933990090
• Mol file: 830-94-4.mol

Synonyms:5-Chlorogramine;5-Chloro-3-[(dimethylamino)methyl]indole;

Chemical Property of 5-CHLOROGRAMINE

Chemical Property:

• Boiling Point: 327.421 °C at 760 mmHg
• Flash Point: 151.819 °C
• PSA: 19.03000
• Density: 1.225 g/cm³
• LogP: 2.88290
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Chlorogramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROGRAMINE

There total 5 articles about 5-CHLOROGRAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-chloro-1H-indole (17422-32-1) + eschenmoser's salt (33797-51-2) → 3-(dimethylaminomethyl)-5-chloro-1H-indole (830-94-4)

Guidance literature:

In dichloromethane;

DOI:10.1021/jm0700619

Reference yield: 61.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-chloro-1H-indole (17422-32-1) + N,N-dimethylammonium chloride (506-59-2) → 3-(dimethylaminomethyl)-5-chloro-1H-indole (830-94-4)

Guidance literature:

With acetic acid; triethylamine; In 1,4-dioxane; water; at 20 ℃; for 23h;

DOI:10.1021/acs.joc.9b00039

Reference yield: 40.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-chloro-1H-indole (17422-32-1) + dimethyl amine (124-40-3) → 3-(dimethylaminomethyl)-5-chloro-1H-indole (830-94-4)

Guidance literature:

formaldehyd; 5-chloro-1H-indole; dimethyl amine; With acetic acid; In tetrahydrofuran; 1,4-dioxane; water; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1002/anie.200904388

upstream raw materials:

5-chloro-1H-indole

eschenmoser's salt

formaldehyd

dimethyl amine

Downstream raw materials:

2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid

2-(5-chloro-1H-indol-3-yl)acetonitrile

C₂₂H₂₂ClF₂N₂O₃P

Refernces

• 1、 Grugel, Christian P.,Breit, Bernhard. "Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines". supporting information. p. 9672 - 9676. Retrieved 2019/12/24.
• 2、 -. "INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 )". Page/Page column 80. . Retrieved 2009/04/25.