2-AMINO-5-(4-BROMOPHENYL)-1,3,4-THIADIAZOLE

Base Information

• Chemical Name: 2-AMINO-5-(4-BROMOPHENYL)-1,3,4-THIADIAZOLE
• CAS No.: 13178-12-6
• Molecular Formula: C8H6BrN3S
• Molecular Weight: 256.126
• Hs Code.: 2934999090
• Mol file: 13178-12-6.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-(p-bromophenyl)- (8CI);5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine;

Chemical Property of 2-AMINO-5-(4-BROMOPHENYL)-1,3,4-THIADIAZOLE

Chemical Property:

• Vapor Pressure: 1.21E-06mmHg at 25°C
• Melting Point: 228-232 °C(lit.)
• Refractive Index: 1.695
• Boiling Point: 401.1 °C at 760 mmHg
• Flash Point: 196.4 °C
• PSA: 80.04000
• Density: 1.717g/cm³
• LogP: 3.13100

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Bromophenyl)-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

Useful:

Technology Process of 2-AMINO-5-(4-BROMOPHENYL)-1,3,4-THIADIAZOLE

There total 11 articles about 2-AMINO-5-(4-BROMOPHENYL)-1,3,4-THIADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Bromobenzoic acid (586-76-5) + thiosemicarbazide (79-19-6) → 5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine (13178-12-6)

Guidance literature:

4-Bromobenzoic acid; thiosemicarbazide; With trichlorophosphate; at 75 ℃; for 0.5h;

With water; for 4h; Reflux;

DOI:10.1016/j.bmc.2014.09.039

Reference yield: 86.0%

2-(4-bromobenzylidene)hydrazine carbothioamide (36449-43-1) → 5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine (13178-12-6)

Guidance literature:

With iron(III) chloride hexahydrate; In ethanol; for 12h; Reflux;

DOI:10.1002/jhet.2779

Reference yield: 84.0%

potassium thioacyanate (333-20-0) + 4-bromo-benzaldehyde (1122-91-4) → 5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine (13178-12-6)

Guidance literature:

With iodine; toluene-4-sulfonic acid hydrazide; In dimethyl sulfoxide; at 100 ℃; for 12h; Sealed tube;

DOI:10.1002/ejoc.201901250

upstream raw materials:

4-Bromobenzoic acid

thiosemicarbazide

(2E)-2-[(4-bromophenyl)methylidene]hydrazine-1-carbothioamide

4-bromo-benzaldehyde

Downstream raw materials:

2--5-(4-bromophenyl)-1,3,4-thiadiazole

N-<5-(4-Bromophenyl-1,3,4-thiadiazol-2-yl)>-3-phenylprop-2-en-1-one

N-<5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl>acrylamide

N-[5-(4-Bromo-phenyl)-[1,3,4]thiadiazol-2-yl]-2-methyl-acrylamide

Refernces

• 1、 -. "Aryl or heteroaryl substituted thiadiazole compound and antibacterial application thereof". Paragraph 0095-0097; 0109-0110. . Retrieved 2021/01/30.
• 2、 Zhang, Xin-Hui,Guo, Qian,Wang, Heng-Ying,Li, Yi-Han,Khamis, Mussa Yussuf,Ma, Li-Ying,Wang, Bo,Liu, Hong-Min. "Gramine-based structure optimization to enhance anti-gastric cancer activity". . . Retrieved 2021/01/07.