4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde

Base Information

• Chemical Name: 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde
• CAS No.: 2426-84-8
• Molecular Formula: C15H13NO5
• Molecular Weight: 287.272
• Hs Code.: 2913000090
• Mol file: 2426-84-8.mol

Synonyms:Benzaldehyde, 4-benzyloxy-5-methoxy-2-nitro-;

Chemical Property of 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde

Chemical Property:

• Vapor Pressure: 1.13E-09mmHg at 25°C
• Melting Point: 133 °C
• Refractive Index: 1.615
• Boiling Point: 488 °C at 760 mmHg
• Flash Point: 218.9 °C
• Density: 1.296 g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde

There total 19 articles about 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (2426-84-8)

Guidance literature:

With potassium nitrate; trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield: 90.0%

6-nitrovanillin (2454-72-0) + benzyl chloride (100-44-7) → 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (2426-84-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 75.0%

(4-benzyloxy-5-methoxy-2-nitro-phenyl)-acetic acid (92964-17-5) → 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (2426-84-8)

Guidance literature:

With benzyltriphenylphosphonium peroxodisulfate; In acetonitrile; for 1h; Heating;

DOI:10.1246/bcsj.71.1649

upstream raw materials:

3-methoxy-4-(phenylmethoxy)benzaldehyde

(4-benzyloxy-5-methoxy-2-nitro-phenyl)-acetic acid

6-nitrovanillin

benzyl chloride

Downstream raw materials:

6-nitrovanillin

4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

2-amino-4-(benzyloxy)-5-methoxybenzaldehyde

4-benzyloxy-6-iodo-3-methoxybenzaldehyde

Refernces

• 1、 Lai, Yu-Sen,Kao, Chai-Lin,Chen, Ya-Pei,Fang, Chia-Chia,Hu, Chao-Chin,Chu, Chih-Chien. "Photodegradable self-assembling PAMAM dendrons for gene delivery involving dendriplex formation and phototriggered circular DNA release". . p. 2601 - 2608. Retrieved 2016.
• 2、 -. "G-A CROSSLINKING CYTOTOXIC AGENTS". Page/Page column 174-175; 193. . Retrieved 2020/08/22.
• 3、 Bhakta, Sanjib,Brucoli, Federico,Ferguson, Lindsay,Fox, Keith R.,Wells, Geoff. "Synthesis and biological evaluation of a novel C8-pyrrolobenzodiazepine (PBD) adenosine conjugate. A study on the role of the PBD ring in the biological activity of PBD-conjugates". supporting information. . Retrieved 2020/03/19.