2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde

Base Information

• Chemical Name: 2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde
• CAS No.: 82583-95-7
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol file: 82583-95-7.mol

Synonyms:LogP

Chemical Property of 2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 198-200 °C
• Refractive Index: 1.626
• Boiling Point: 447.614 °C at 760 mmHg
• Flash Point: 216.37 °C
• PSA: 61.55000
• Density: 1.213 g/cm³
• LogP: 3.25010

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde

There total 5 articles about 2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (2426-84-8) → 2-amino-4-(benzyloxy)-5-methoxybenzaldehyde (82583-95-7)

Guidance literature:

With formamide; zinc; In ethanol; for 8h; Reflux;

DOI:10.1002/ardp.200800035

Reference yield:

6-nitro-1,3-benzodioxole-5-carbaldehyde (712-97-0) → 2-amino-4-(benzyloxy)-5-methoxybenzaldehyde (82583-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / methanol; dimethylsulfoxide; dimethylformamide / 2 h / 150 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 2 h / 100 °C

3: FeSO₄*7H₂O, 25 percent NH₄OH / 0.08 h / 100 °C

With ammonium hydroxide; potassium carbonate; iron(II) sulfate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

6-nitrovanillin (2454-72-0) → 2-amino-4-(benzyloxy)-5-methoxybenzaldehyde (82583-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 2 h / 100 °C

2: FeSO₄*7H₂O, 25 percent NH₄OH / 0.08 h / 100 °C

With ammonium hydroxide; potassium carbonate; iron(II) sulfate; In N,N-dimethyl-formamide;

upstream raw materials:

4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

6-nitrovanillin

6-nitro-1,3-benzodioxole-5-carbaldehyde

4-Benzyloxy-5-hydroxy-2-nitro-benzaldehyde

Refernces

• 1、 Liu, Yajing,Zhao, Yanfang,Zhai, Xin,Liu, Xiuping,Sun, Lixue,Ren, Yanxia,Gong, Ping. "Synthesis and anti-HBV activities evaluation of new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives in vitro". experimental part. p. 446 - 452. Retrieved 2009/04/11.