1-PHENOXY-2-PROPANOL

Base Information

• Chemical Name: 1-PHENOXY-2-PROPANOL
• CAS No.: 130879-97-9
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.193
• Mol file: 130879-97-9.mol

Synonyms:2-Propanol,1-phenoxy-, (S)-; (+)-1-Phenoxy-2-propanol; (S)-1-Phenoxy-2-propanol

Chemical Property of 1-PHENOXY-2-PROPANOL

Chemical Property:

• Vapor Pressure: 0.02mmHg at 25°C
• Melting Point: 11℃
• Refractive Index: n20/D 1.523(lit.)
• Boiling Point: 243℃(lit.)
• Flash Point: >230℉
• PSA: 29.46000
• Density: 1.064g/mLat20℃(lit.)
• LogP: 1.44620

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 23-26

MSDS Files:

Useful:

Technology Process of 1-PHENOXY-2-PROPANOL

There total 65 articles about 1-PHENOXY-2-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-phenoxy-2-propanone (621-87-4) → 1-phenoxy-2-propanol (770-35-4,130879-97-9)

Guidance literature:

With formic acid; C₃₃H₃₃ClIrNO; sodium formate; In water; at 80 ℃; for 14h; pH=4.5; Reagent/catalyst; chemoselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1002/chem.201403701

Reference yield: 89.0%

4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7) → 1-phenoxy-2-propanol (770-35-4,130879-97-9)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1039/a902213i

Reference yield: 73.0%

Phenyl glycidyl ether (122-60-1,71031-02-2) + nitrobenzene (98-95-3,26969-40-4) → 1-phenoxy-2-propanol (770-35-4,130879-97-9) + N-(2-hydroxy-3-phenoxypropyl)aniline (16112-55-3,113279-34-8) + aniline (62-53-3)

Guidance literature:

With palladium on activated charcoal; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In ethanol; Reflux;

DOI:10.1055/s-0029-1218380

upstream raw materials:

3-phenoxy-2-propanone

sodium phenoxide

1-Chloro-2-propanol

phenol

Downstream raw materials:

Acetic acid (R)-1-methyl-2-phenoxy-ethyl ester

(R)-N-benzyl-1-phenoxypropan-2-amine

C₁₈H₂₂ClNO*ClH

C₁₈H₂₃NO₂

Refernces

• 1、 Corma, Avelino,Domine, Marcelo E.,Valencia, Susana. "Water-resistant solid Lewis acid catalysts: Meerwein-Ponndorf-Verley and Oppenauer reactions catalyzed by tin-beta zeolite". . p. 294 - 304. Retrieved 2003.
• 2、 Anthonsen, Henrik W.,Hoff, Bard Helge,Anthonsen, Thorleif. "A SIMPLE METHOD FOR CALCULATING ENANTIOMER RATIO AND EQUILIBRIUM CONSTANTS IN BIOCATALYTIC RESOLUTIONS". . p. 3015 - 3022. Retrieved 1995.
• 3、 Andreu, Cecilia,del Olmo, Marcel?lí. "Improved Biocatalytic Activity of the Debaryomyces Species in Seawater". . p. 3085 - 3092. Retrieved 2019.
• 4、 Lambert, Tristan H.,Steiniger, Keri A.. "Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides". supporting information. p. 8013 - 8017. Retrieved 2021/10/25.
• 5、 -. "CATALYST FOR PREPARING PROPYLENE GLYCOL PHENYL ETHER AND METHOD FOR SYNTHESIZING PROPYLENE GLYCOL PHENYL ETHER". Paragraph 0022-0049. . Retrieved 2020/06/08.