5-BROMO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-BROMO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID
• CAS No.: 40197-20-4
• Molecular Formula: C8H5BrN2O2
• Molecular Weight: 241.044
• Hs Code.: 2933990090
• Mol file: 40197-20-4.mol

Synonyms:1H-Benzimidazole-2-carboxylicacid, 5-bromo- (9CI);2-Benzimidazolecarboxylic acid, 5(or 6)-bromo- (6CI);

Chemical Property of 5-BROMO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 206oC
• Boiling Point: 494.631 °C at 760 mmHg
• PKA: 1.30±0.30(Predicted)
• Flash Point: 252.944 °C
• PSA: 65.98000
• Density: 1.947 g/cm³
• LogP: 2.02360
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1H-benzoimidazole-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-BROMO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID

There total 4 articles about 5-BROMO-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(5-bromo-1H-benzo[d]imidazol-2-yl)methanol (540516-28-7) → 5-bromo-1H-benzo[d]imidazole-2-carboxylic acid (40197-20-4)

Guidance literature:

With potassium permanganate; In water; acetone;

DOI:10.3390/molecules200815206

Reference yield:

4-Bromo-benzene-1,2-diamine (1575-37-7) → 5-bromo-1H-benzo[d]imidazole-2-carboxylic acid (40197-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 8 h / Reflux

2: potassium permanganate / water; acetone

With hydrogenchloride; potassium permanganate; In water; acetone;

DOI:10.3390/molecules200815206

Reference yield:

→ 2-Carboxy-6-brombenzimidazol (40197-20-4)

Guidance literature:

entspr. Benzimidazol, Brom;

upstream raw materials:

(5-bromo-1H-benzo[d]imidazol-2-yl)methanol

4-Bromo-benzene-1,2-diamine

Refernces

• 1、 -. "CARBAMATE COMPOUND OR SALT THEREOF". Page/Page column 16. . Retrieved 2011/08/08.