2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE
• CAS No.: 5739-10-6
• Molecular Formula: C5H9N3
• Molecular Weight: 111.147
• Hs Code.: 2933290090
• Mol file: 5739-10-6.mol

Synonyms:Imidazole,1-(2-aminoethyl)- (8CI);1-(2-Aminoethyl)imidazole;2-(1H-Imidazol-1-yl)ethanamine;2-(1H-Imidazol-1-yl)ethylamine;2-Imidazol-1-ylethylamine;Imidazole-1-ethylamine;N-(2-Aminoethyl)imidazole;

Chemical Property of 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 283.463 °C at 760 mmHg
• PKA: 7.51±0.10(Predicted)
• Flash Point: 125.234 °C
• PSA: 43.84000
• Density: 1.153 g/cm³
• LogP: 0.54210
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Imidazol-1-yl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE

There total 9 articles about 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C6H10N4O (1190617-85-6) → N-[2-(aminoethyl)]imidazole (5739-10-6)

Guidance literature:

With hydrogenchloride; sodium nitrate; In water; at 0 - 80 ℃; for 7h;

Reference yield: 74.0%

2-[2-(1H-imidazol-1-yl)ethyl]-isoindole-1,3(2H)-dione (72459-53-1) → N-[2-(aminoethyl)]imidazole (5739-10-6)

Guidance literature:

With hydrazine; In ethanol; for 16h; Heating;

DOI:10.1016/j.bmcl.2007.11.102

Reference yield: 34.0%

1H-imidazole (288-32-4) + 2-chloroethanamine hydrochloride (870-24-6) → N-[2-(aminoethyl)]imidazole (5739-10-6)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In acetonitrile; for 21h; Heating / reflux;

upstream raw materials:

2-[2-(1H-imidazol-1-yl)ethyl]-isoindole-1,3(2H)-dione

1H-imidazole

2-chloroethanamine hydrochloride

(2-imidazol-1-yl-ethyl)-carbamic acid tert-butyl ester

Downstream raw materials:

N-[3-Chlorophenyl]-N'-[2-(1H-imidazole-1-yl)ethyl]urea

N-{N-[2-(imidazol-1-yl)ethyl]carbamoyl}-5(S)-3,9,10,11-tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-ylamine

Refernces

• 1、 -. "CINNAMIC ACID AMIDE DERIVATIVE". Paragraph 0028; 0057. . Retrieved 2015/11/24.
• 2、 Bergstrom, Carl P.,Sloan, Charles P.,Lau, Wai-Yu,Smith, David W.,Zheng, Ming,Hansel, Steven B.,Polson, Craig T.,Corsa, Jason A.,Barten, Donna M.,Felsenstein, Kevin M.,Roberts, Susan B.. "Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase". . p. 464 - 468. Retrieved 2008/12/21.