4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine

Base Information

• Chemical Name: 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine
• CAS No.: 907547-83-5
• Molecular Formula: C₁₇H₁₅N₃O₂
• Molecular Weight: 293.325
• Mol file: 907547-83-5.mol

Synonyms:4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine

Chemical Property of 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine

There total 5 articles about 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

7-methoxoyflavone (22395-22-8) + guanidine hydrochloride (50-01-1) → 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine (907547-83-5)

Guidance literature:

With potassium hydroxide; In methanol; Reflux;

DOI:10.1016/j.ejmech.2012.01.035

Reference yield:

1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione (52752-67-7) → 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine (907547-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; acetic acid / 1 h / 100 °C

2: potassium hydroxide / methanol / Reflux

With sulfuric acid; acetic acid; potassium hydroxide; In methanol;

DOI:10.1016/j.ejmech.2012.01.035

Reference yield:

benzoic acid 2-acetyl-5-methoxyphenyl ester (124260-01-1) → 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine (907547-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; potassium hydroxide / 2 h / 20 °C

2: sulfuric acid; acetic acid / 1 h / 100 °C

3: potassium hydroxide / methanol / Reflux

With pyridine; sulfuric acid; acetic acid; potassium hydroxide; In methanol; 1: Baker-Venkataraman transformation;

DOI:10.1016/j.ejmech.2012.01.035

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)ethanone

1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

7-methoxoyflavone

guanidine hydrochloride

Refernces