7-METHOXYFLAVONE

Base Information

• Chemical Name: 7-METHOXYFLAVONE
• CAS No.: 22395-22-8
• Molecular Formula: C16H12O3
• Molecular Weight: 252.269
• Hs Code.: 29145019
• Mol file: 22395-22-8.mol

Synonyms:7-Methoxy-2-phenyl-4H-chromen-4-one;

Chemical Property of 7-METHOXYFLAVONE

Chemical Property:

• Vapor Pressure: 8.75E-08mmHg at 25°C
• Melting Point: 110-112 °C(lit.)
• Refractive Index: 1.587
• Boiling Point: 421.2±45.0 °C at 760 mmHg
• Flash Point: 200.3±15.1 °C
• PSA: 39.44000
• Density: 1.2±0.1 g/cm³
• LogP: 3.46860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxy-2-phenyl-4H-chromen-4-one ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: 7-Methoxyflavone is a natural compound and non-steroidal because it binds reversibly with aromatase which is an enzyme that helps produce estrogen through the conversion of androgen (testosterone) to estrogen. It has strong aromatase inhibiting properties, superior bioavailability, and strong resistance to hepatic metabolism/breakdown.

Technology Process of 7-METHOXYFLAVONE

There total 70 articles about 7-METHOXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-methoxyflavanone (21785-09-1) → 7-methoxoyflavone (22395-22-8)

Guidance literature:

With pyrrolidone hydrotribromide; In dimethyl sulfoxide; at 80 ℃; for 2.5h;

DOI:10.1246/bcsj.58.1599

Reference yield: 91.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + α-bromoacetophenone (70-11-1) → 7-methoxoyflavone (22395-22-8)

Guidance literature:

With 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/ejoc.201701435

Reference yield: 90.0%

p-methoxybenzoylmethanol (4136-21-4) + benzaldehyde (100-52-7) → 7-methoxoyflavone (22395-22-8)

Guidance literature:

With 1-butyl-3-methylimidazolium molybdate; oxygen; at 70 ℃; for 6h; under 3000.3 Torr;

upstream raw materials:

tetrachloromethane

N-Bromosuccinimide

7-methoxyflavanone

dibenzoyl peroxide

Downstream raw materials:

4-(2-hydroxy-4-methoxyphenyl)-6-phenyl-2-aminopyrimidine

7-hydroxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde

7-methoxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde

7-methoxy-4-methyl-2-phenylchromenylium chloride

Refernces

• 1、 Son, Seung Hwan,Cho, Yang Yil,Yoo, Hyung-Seok,Lee, Soo Jin,Kim, Young Min,Jang, Hyu Jeong,Kim, Dong Hwan,Shin, Jeong-Won,Kim, Nam-Jung. "Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization". . p. 14000 - 14006. Retrieved 2021/04/22.
• 2、 Tamuli, Kashyap J.,Sahoo, Ranjan K.,Bordoloi, Manobjyoti. "Biocatalytic green alternative to existing hazardous reaction media: Synthesis of chalcone and flavone derivatives via the Claisen-Schmidt reaction at room temperature". supporting information. p. 20956 - 20965. Retrieved 2020/12/31.