2,5-Dichloropyridine-3-carbonyl chloride

Base Information

• Chemical Name: 2,5-Dichloropyridine-3-carbonyl chloride
• CAS No.: 78686-87-0
• Molecular Formula: C6H2Cl3NO
• Molecular Weight: 210.447
• Hs Code.: 2933399090
• European Community (EC) Number: 692-339-1
• DSSTox Substance ID: DTXSID00384130
• Wikidata: Q82176080
• Mol file: 78686-87-0.mol

Synonyms:2,5-dichloropyridine-3-carbonyl chloride;78686-87-0;2,5-Dichloronicotinoyl chloride;2,5-Dichloro-nicotinoyl chloride;2,5-dichloropyridine-3-carbonylchloride;2,5-dichloro-3-pyridinecarbonyl chloride;2,5-dichloronicotinic acid chloride;2,5-Dichloronicotinoylchloride;SCHEMBL1160933;DTXSID00384130;VRJMAKCJTSZUQR-UHFFFAOYSA-N;MFCD00210149;AKOS007930904;2,5-Dichloro-pyridine-nicotinoyl chloride;CS-10581;2,5-dichloro-pyridine-3-carbonyl chloride;CS-0268503;FT-0610329;EN300-1459139;2,5-dichloropyridine-3-carbonyl chloride, AldrichCPR

Chemical Property of 2,5-Dichloropyridine-3-carbonyl chloride

Chemical Property:

• Vapor Pressure: 0.00745mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 269 °C at 760 mmHg
• Flash Point: 116.5 °C
• PSA: 29.96000
• Density: 1.582 g/cm³
• LogP: 2.76740
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 208.920197
• Heavy Atom Count: 11
• Complexity: 164

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dichloropyridine-3-carbonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1C(=O)Cl)Cl)Cl

Technology Process of 2,5-Dichloropyridine-3-carbonyl chloride

There total 1 articles about 2,5-Dichloropyridine-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-hydroxypyridine-3-carboxylic acid (38076-80-1) → 2,5-dichloronicotinoyl chloride (78686-87-0)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1021/jm00070a012

Reference yield: 94.0%

2,5-dichloronicotinoyl chloride (78686-87-0) → 2,5-dichloropyridine-3-carboxamide (75291-86-0)

Guidance literature:

With ammonia; In 1,4-dioxane; water; at 0 ℃; for 0.166667h;

Reference yield: 64.0%

1-(4-amino-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one (1186375-59-6) + 2,5-dichloronicotinoyl chloride (78686-87-0) → 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide (1186376-03-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

5-chloro-2-hydroxypyridine-3-carboxylic acid

Downstream raw materials:

2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

2,5-dichloro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)nicotinamide

(S)-N-((3-(3,5-difluoro-4-(2-chloro-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)-phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

2,5-dichloropyridine-3-carboxamide

Refernces

• 1、 Winn, Martin,De, Biswanath,Zydowsky, Thomas M.,Altenbach, Robert J.,Basha, Fatima Z.,et al.. "2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists". . p. 2676 - 2688. Retrieved 2007/10/02.