5-Chloro-2-hydroxynicotinic acid

Base Information

• Chemical Name: 5-Chloro-2-hydroxynicotinic acid
• CAS No.: 38076-80-1
• Molecular Formula: C6H4ClNO3
• Molecular Weight: 173.556
• Hs Code.: 29333990
• Mol file: 38076-80-1.mol

Synonyms:2-Hydroxy-5-chloronicotinicacid;5-Chloro-2-hydroxy-3-pyridinecarboxylic acid;5-Chloro-2-hydroxynicotinicacid;

Chemical Property of 5-Chloro-2-hydroxynicotinic acid

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Melting Point: 260 °C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• PSA: 70.42000
• Density: 1.62 g/cm³
• LogP: 1.13880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2-hydroxynicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-hydroxynicotinic acid

There total 2 articles about 5-Chloro-2-hydroxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

2-hydroxy-3-carboxypyridine (609-71-2) → 5-chloro-2-hydroxypyridine-3-carboxylic acid (38076-80-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium hypochlorite; chlorine; sodium hydrogensulfite; In water; acetone;

Reference yield: 81.8%

2-hydroxy-3-carboxypyridine (609-71-2) + di-isopropyl ether (108-20-3) + 3,5-Dichloro-2-pyridinol (5437-33-2) → 5-chloro-2-hydroxypyridine-3-carboxylic acid (38076-80-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In sodium hypochlorite; water;

Reference yield: 91.0%

5-chloro-2-hydroxypyridine-3-carboxylic acid (38076-80-1) → 2,5-dichloronicotinic acid (59782-85-3)

Guidance literature:

With sulfuryl dichloride; In N,N-dimethyl-formamide; for 2h; Heating;

upstream raw materials:

2-hydroxy-3-carboxypyridine

di-isopropyl ether

3,5-Dichloro-2-pyridinol

Downstream raw materials:

2,5-dichloronicotinic acid

2,5-dichloronicotinoyl chloride

methyl 2,5-dichloronicotinate

methyl-5-chloro-2-propylaminonicotinate

Refernces

• 1、 Winn, Martin,De, Biswanath,Zydowsky, Thomas M.,Altenbach, Robert J.,Basha, Fatima Z.,et al.. "2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists". . p. 2676 - 2688. Retrieved 2007/10/02.
• 2、 Gero, Thomas W.,Jaques, Larry W.,Mays, Richard P.,Reid, Debra H.,Shamblee, Dwight A.,et al.. "HALOGENATION OF 2-HYDROXYNICOTINIC ACID". . p. 553 - 560. Retrieved 2007/10/02.