1,2-propyleneglycol-1-triphenylmethyl ether

Base Information

• Chemical Name: 1,2-propyleneglycol-1-triphenylmethyl ether
• CAS No.: 71697-18-2
• Molecular Formula: C₂₂H₂₂O₂
• Molecular Weight: 318.415
• Mol file: 71697-18-2.mol

Synonyms:1,2-propyleneglycol-1-triphenylmethyl ether

Chemical Property of 1,2-propyleneglycol-1-triphenylmethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-propyleneglycol-1-triphenylmethyl ether

There total 3 articles about 1,2-propyleneglycol-1-triphenylmethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

propylene glycol (57-55-6,63625-56-9) + trityl chloride (76-83-5) → 1,2-propyleneglycol-1-triphenylmethyl ether (71697-18-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetasy.2011.10.003

Reference yield:

trityl 2-hydroxyethyl ether (18325-45-6) → 1,2-propyleneglycol-1-triphenylmethyl ether (71697-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux

2: diethyl ether / 0 °C

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In diethyl ether; ethyl acetate;

DOI:10.1002/chem.201200694

Reference yield:

α-trityloxyacetaldehyde (3292-82-8) + methylmagnesium bromide (75-16-1) → 1,2-propyleneglycol-1-triphenylmethyl ether (71697-18-2)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1002/chem.201200694

upstream raw materials:

propylene glycol

trityl chloride

trityl 2-hydroxyethyl ether

α-trityloxyacetaldehyde

Downstream raw materials:

1-Triphenylmethoxy-propyl-⁽²⁾-palmitat

(S)-1-triphenylmethoxypropan-2-ol

(R)-1-triphenylmethylmethoxy-2-propanol

(R)-1-triphenylmethyloxy-2-acetoxypropane

Refernces

• 1、 Aguillón, Anderson R.,Avelar, Marcelo N.,Gotardo, Larissa E.,de Souza, Stefania P.,Le?o, Raquel A.C.,Itabaiana, Ivaldo,Miranda, Leandro S.M.,de Souza, Rodrigo O.M.A.. "Immobilized lipase screening towards continuous-flow kinetic resolution of (±)-1,2-propanediol". . p. 128 - 134. Retrieved 2019/02/12.
• 2、 -. "N-Substituted Benzenepropanamide and Benzenepropenamide For Use in the Prevention or the Treatment of Affective Disorders". Paragraph 0094. . Retrieved 2014/09/30.