2-methyl-4,5,6,7-四氢苯并噻唑

Base Information

• Chemical Name: 2-methyl-4,5,6,7-四氢苯并噻唑
• CAS No.: 33082-03-0
• Molecular Formula: C₈H₁₁NS
• Molecular Weight: 153.248
• Mol file: 33082-03-0.mol

Synonyms:2-methyl-4,5,6,7-tetrahydro-benzothiazole

Chemical Property of 2-methyl-4,5,6,7-四氢苯并噻唑

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4,5,6,7-tetrahydro-2-methyl-Benzothiazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4,5,6,7-四氢苯并噻唑

There total 6 articles about 2-methyl-4,5,6,7-四氢苯并噻唑 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Chlor-7-oxa-bicyclo<4.1.0>heptan (51595-54-1) + thioacetamide (62-55-5) → 2-methyl-4,5,6,7-tetrahydro-benzothiazole (33082-03-0)

Guidance literature:

With 4 A molecular sieve; In methanol; dichloromethane; at 40 ℃; for 24h;

DOI:10.1016/S0040-4020(01)98964-1

Reference yield: 58.0%

thioacetamide (62-55-5) + 2-Chlorocyclohexanone (822-87-7) → 2-methyl-4,5,6,7-tetrahydro-benzothiazole (33082-03-0)

Guidance literature:

thioacetamide; 2-Chlorocyclohexanone; In ethanol; Reflux;

With sodium carbonate; In ethanol;

Reference yield:

2-methyl-2,4,5,6,7,7a-hexahydro-benzothiazole (98426-92-7) → 2-methyl-4,5,6,7-tetrahydro-benzothiazole (33082-03-0)

Guidance literature:

With sulfur; at 150 ℃; for 2h;

upstream raw materials:

2-bromocyclohexanone

thioacetamide

2-methyl-2,4,5,6,7,7a-hexahydro-benzothiazole

methyl-2 oxo-7 tetrahydro-4,5,6,7 benzothiazole

Downstream raw materials:

3-Amino-2-methyl-5,6,7,8-tetrahydropyrazolo[3,2-b]-benzothiazole hydrochloride

2-methyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-benzothiazolium; bromide

Refernces

• 1、 Gasteiger, Johann,Herzig, Christian. "SYNTHETIC APPLICATIONS OF 2-CHLOROOXIRANES: PREPARATION OF THIAZOLES, DIHYDROTHIAZOLES AND SELENAZOLES". . p. 2607 - 2611. Retrieved 2007/10/02.