C₁₂H₂₇O₂PSi

Base Information

• Chemical Name: C₁₂H₂₇O₂PSi
• CAS No.: 848773-35-3
• Molecular Formula: C₁₂H₂₇O₂PSi
• Molecular Weight: 262.404
• Mol file: 848773-35-3.mol

Synonyms:C₁₂H₂₇O₂PSi

Chemical Property of C₁₂H₂₇O₂PSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₂₇O₂PSi

There total 4 articles about C₁₂H₂₇O₂PSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-diethoxyethyl(cyclohexylmethyl)phosphinic acid ethyl ester (153994-66-2) → C12H27O2PSi (848773-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 24 h / Ambient temperature

With chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00017a016

Reference yield:

chloro-trimethyl-silane (75-77-4) + P-(cyclohexylmethyl)phosphinic acid ethyl ester (133457-82-6) → C12H27O2PSi (848773-35-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jm00017a016

Reference yield:

1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) + P-(cyclohexylmethyl)phosphinic acid ethyl ester (133457-82-6) → C12H27O2PSi (848773-35-3)

Guidance literature:

With ammonium sulfate; at 128 ℃; for 22 - 26h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

chloro-trimethyl-silane

P-(cyclohexylmethyl)phosphinic acid ethyl ester

1,1-diethoxyethyl(cyclohexylmethyl)phosphinic acid ethyl ester

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

Cyclohexylmethyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester

O-ethyl (3-chloro-(2S)-trimethylsilyloxypropyl)(cyclohexylmethyl)phosphinate

Refernces

• 1、 Froestl,Mickel,Von Sprecher,Diel,Hall,Maier,Strub,Melillo,Baumann,Bernasconi,Gentsch,Hauser,Jaekel,Karlsson,Klebs,Maitre,Marescaux,Pozza,Schmutz,et al.. "Phosphinic acid analogues of GABA. 2. Selective, orally active GABA(B) antagonists". . p. 3313 - 3331. Retrieved 2007/10/02.