methyl 4-fluoro-α-hydroxyphenylacetate

Base Information

• Chemical Name: methyl 4-fluoro-α-hydroxyphenylacetate
• CAS No.: 127709-19-7
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.167
• Hs Code.: 2918199890
• Mol file: 127709-19-7.mol

Synonyms:methyl 4-fluoro-α-hydroxyphenylacetate

Chemical Property of methyl 4-fluoro-α-hydroxyphenylacetate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Methyl (4-fluorophenyl)(hydroxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-fluoro-α-hydroxyphenylacetate

There total 11 articles about methyl 4-fluoro-α-hydroxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (p-fluorobenzoyl)formate (156276-23-2) → methyl 4-fluoro-α-hydroxyphenylacetate (127709-19-7,32222-46-1)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate; In methanol; at 25 ℃; for 12h; under 7500.75 Torr; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1055/s-0035-1561971

Reference yield: 87.0%

4-fluoromandelic acid (32222-45-0,52923-25-8,52950-15-9,395-33-5) + methyl iodide (74-88-4) → methyl 4-fluoro-α-hydroxyphenylacetate (127709-19-7,32222-46-1)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield: 85.0%

methanol (67-56-1) + 4-fluoromandelic acid (32222-45-0,52923-25-8,52950-15-9,395-33-5) → methyl 4-fluoro-α-hydroxyphenylacetate (127709-19-7,32222-46-1)

Guidance literature:

With sulfuric acid; at 60 ℃;

DOI:10.1016/j.bmcl.2018.01.059

upstream raw materials:

methanol

4-fluoromandelic acid

methyl iodide

1-methyl-1-nitrosourea

Downstream raw materials:

C₁₃H₁₅FO₅

methyl 2-(4-fluorophenyl)-2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)acetate

C₁₃H₁₃FO₄

(4-fluoro-phenyl)-hydroxy-acetic acid methyl ester

Refernces

• 1、 Gao, Yang,Zhang, Xuexin,Laishram, Ronibala Devi,Chen, Jingchao,Li, Kangkui,Zhang, Keyang,Zeng, Guangzhi,Fan, Baomin. "Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source". supporting information. p. 3991 - 3997. Retrieved 2019/08/02.
• 2、 -. "A containing "1, 3, 4 - oxadiazole thioether" mandelic acid derivatives and use thereof". Paragraph 0051-0054. . Retrieved 2019/01/06.