N-METHYL-2-NITROBENZYLAMINE

Base Information

• Chemical Name: N-METHYL-2-NITROBENZYLAMINE
• CAS No.: 56222-08-3
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2921499090
• Mol file: 56222-08-3.mol

Synonyms:(2-Nitrobenzyl)methylamine;(Methyl)(2-nitrobenzyl)amine;N-Methyl-2-nitrobenzenemethanamine;

Chemical Property of N-METHYL-2-NITROBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.0205mmHg at 25°C
• Refractive Index: n20/D 1.5580(lit.)
• Boiling Point: 251.4 °C at 760 mmHg
• PKA: 8.89±0.10(Predicted)
• Flash Point: 105.8 °C
• PSA: 57.85000
• Density: 1.162 g/cm³
• LogP: 2.22830
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Nitro-N-methylbenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant involved in the synthesis of biologically active molecules including:Calmodulin kinase II inhibitorsAP2238 derivativesCholinesterase inhibitorsAzole antifungal agents

Technology Process of N-METHYL-2-NITROBENZYLAMINE

There total 11 articles about N-METHYL-2-NITROBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-nitrobenzylidene)methanamine (57707-11-6) → (2-nitrobenzyl)methylamine (56222-08-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2006.09.026

Reference yield: 98.0%

(2-nitrophenyl)methyl methanesulfonate (163915-96-6) + methylamine (74-89-5) → (2-nitrobenzyl)methylamine (56222-08-3)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 2.5h;

DOI:10.1039/c8md00479j

Reference yield: 95.0%

methylamine (74-89-5) + 2-nitro-benzaldehyde (552-89-6) → (2-nitrobenzyl)methylamine (56222-08-3)

Guidance literature:

methylamine; 2-nitro-benzaldehyde; In methanol; water; at 20 ℃; for 1.5h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; water; at 20 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1002/anie.201609733

upstream raw materials:

bromocyane

(2-iodo-benzyl)-methyl-(2-nitro-benzyl)-amine

2-nitrobenzyl chloride

methylamine

Downstream raw materials:

tert-butyl (2-aminobenzyl)(methyl)carbamate

Refernces

• 1、 Speri, Enrico,Fishovitz, Jennifer,Mobashery, Shahriar. "Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant: Staphylococcus aureus (MRSA)". . p. 2008 - 2016. Retrieved 2019/01/04.
• 2、 -. "GLUCURONIDE PRODRUGS OF JANUS KINASE INHIBITORS". Paragraph 0416; 0417. . Retrieved 2018/12/11.