3-Biphenylmethanol

Base Information

• Chemical Name: 3-Biphenylmethanol
• CAS No.: 69605-90-9
• Molecular Formula: C13H12O
• Molecular Weight: 705.894
• Hs Code.: 2906299090
• Mol file: 69605-90-9.mol

Synonyms:3-Biphenylmethanol(6CI);3-Hydroxymethyl-1,1'-biphenyl;3-Phenylbenzyl alcohol;Biphenyl-3-ylmethanol;

Chemical Property of 3-Biphenylmethanol

Chemical Property:

• Vapor Pressure: 4.94E-05mmHg at 25°C
• Melting Point: 48.0 to 52.0 °C
• Refractive Index: 1.595
• Boiling Point: 334.8 °C at 760 mmHg
• Flash Point: 151.9 °C
• PSA: 20.23000
• Density: 1.093 g/cm³
• LogP: 2.84590

Purity/Quality:

99% ^*data from raw suppliers

[1,1''-Biphenyl]-3-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Biphenylmethanol

There total 40 articles about 3-Biphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

biphenyl-3-carboxylic acid ethyl ester (19926-50-2) → 3-phenyl-benzyl alcohol (69605-90-9)

Guidance literature:

With diisobutylaluminium hydride; at 20 ℃;

DOI:10.1016/j.ejmech.2006.11.013

Reference yield: 95.0%

3-phenylbenzoic acid (716-76-7) → 3-phenyl-benzyl alcohol (69605-90-9)

Guidance literature:

3-phenylbenzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.75h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃;

Reference yield: 95.0%

bromobenzene (108-86-1,52753-63-6) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → 3-phenyl-benzyl alcohol (69605-90-9)

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 0.75h;

DOI:10.3762/bjoc.7.41

upstream raw materials:

3-phenylbenzoic acid

p-phenylbenzyl bromide

2-biphenylmethanol

3-(methoxymethyl)-1,1'-biphenyl

Downstream raw materials:

(3-phenylphenyl)methyl pyridin-2-yl carbonate

1-(3-phenylphenyl)methyl 2-oxopyridine-1-carboxylate

(3-phenylphenyl)-methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

1,1-dimethyl-4-(3-phenylbenzyl)semicarbazide

Refernces

• 1、 -. "AMINOPEPTIDASE A INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME". Page/Page column 54-55. . Retrieved 2020/06/10.
• 2、 Meka, Suresh,Rao, Maddali L. N.. "Pd-catalyzed atom-efficient cross-coupling of triarylbismuth reagents with protecting group-free iodophenylmethanols: Synthesis of biarylmethanols". supporting information. . Retrieved 2020/02/11.