1-CBZ-(R)-3-METHYLPIPERAZINE

Base Information

• Chemical Name: 1-CBZ-(R)-3-METHYLPIPERAZINE
• CAS No.: 623586-00-5
• Molecular Formula: C13H18 N2 O2
• Molecular Weight: 234.298
• Hs Code.: 2933599090
• Mol file: 623586-00-5.mol

Synonyms:Benzyl(3R)-3-methylpiperazine-1-carboxylate

Chemical Property of 1-CBZ-(R)-3-METHYLPIPERAZINE

Chemical Property:

• Vapor Pressure: 2.62E-05mmHg at 25°C
• Boiling Point: 358°C at 760 mmHg
• PKA: 8.50±0.40(Predicted)
• Flash Point: 170.3°C
• PSA: 41.57000
• Density: 1.105g/cm³
• LogP: 2.68560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-Benzyl3-Methylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CBZ-(R)-3-METHYLPIPERAZINE

There total 1 articles about 1-CBZ-(R)-3-METHYLPIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-methylpiperazine (75336-86-6) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (3R)-3-methylpiperazine-1-carboxylate (623586-00-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 90.0%

benzyl (3R)-3-methylpiperazine-1-carboxylate (623586-00-5) + 2,4-dichloro-6-phenyl-pyrimidine (26032-72-4) → (R)-4-(2-chloro-6-phenylpyrimidin-4-yl)-3-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:

With palladium diacetate; 1,4-di(diphenylphosphino)-butane; lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/ol052578p

Reference yield: 78.0%

benzyl (3R)-3-methylpiperazine-1-carboxylate (623586-00-5) + (2R,5R)-5-chloromethyl-4-{2-[6-(4-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-piperazine-1-carboxylic acid tert-butyl ester (1403903-28-5) → (2R,5S)-tert-butyl 5-(((R)-4-((benzyloxy)carbonyl)-2-methylpiperazin-1-yl)methyl)-4-(2-(6-(4-fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-oxoethyl)-2-methylpiperazine-1-carboxylate

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 18h;

upstream raw materials:

(2R)-methylpiperazine

benzyl chloroformate

Downstream raw materials:

(R,E)-benzyl 4-(N,N'-(bis(tert-butoxycarbonyl))carbamimidoyl)-3-methylpiperazine-1-carboxylate

Refernces