(S)-(-)-2-Formamidosuccinic anhydride

Base Information

• Chemical Name: (S)-(-)-2-Formamidosuccinic anhydride
• CAS No.: 33605-73-1
• Molecular Formula: C5H5 N O4
• Molecular Weight: 143.099
• Hs Code.: 2924199090
• European Community (EC) Number: 251-589-8
• Nikkaji Number: J92.446F
• Mol file: 33605-73-1.mol

Synonyms:33605-73-1;(S)-(-)-2-Formamidosuccinic anhydride;N-formyl-L-aspartic anhydride;N-formyl-aspartic anhydride;N-[(3S)-2,5-DIOXOOXOLAN-3-YL]FORMAMIDE;(S)-()-2-Formamidosuccinic anhydride;formyl-L-aspartic anhydride;N-formyl aspartic anhydride;formyl aspartic acid anhydride;N-formyl-L aspartic anhydride;SCHEMBL6764272;DFTMVZIUYVECNW-VKHMYHEASA-N;N-formyl-L-aspartic acid anhydride;N-formyl-L-aspartic aicd anhydride;(S)-(-)-2-formamidosuccinicanhydride;AKOS006237205;NS00058992;J-019267;(S)-(-)-2-Formamidosuccinic anhydride, technical grade, 90%

Chemical Property of (S)-(-)-2-Formamidosuccinic anhydride

Chemical Property:

• Vapor Pressure: 1.34E-09mmHg at 25°C
• Melting Point: 145-155 °C (dec.)(lit.)
• Boiling Point: 486 °C at 760 mmHg
• Flash Point: 247.7 °C
• PSA: 72.47000
• Density: 1.44 g/cm³
• LogP: -0.39870
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 143.02185764
• Heavy Atom Count: 10
• Complexity: 188

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-(-)-2-FormamidosuccinicAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(C(=O)OC1=O)NC=O
• Isomeric SMILES: C1[C@@H](C(=O)OC1=O)NC=O

Technology Process of (S)-(-)-2-Formamidosuccinic anhydride

There total 1 articles about (S)-(-)-2-Formamidosuccinic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → n-formylaspartic anhydride (33605-73-1)

Guidance literature:

With acetic anhydride; In formic acid;

Reference yield:

N-formyl-β-L-aspartyl-L-phenylalanine + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + n-formylaspartic anhydride (33605-73-1) → N-formyl-L-α-aspartyl-L-phenylalanine (56633-51-3)

Guidance literature:

With hydrogenchloride; potassium hydroxide; sodium hydroxide; In water;

Reference yield:

N-(2,5-Dioxo-tetrahydro-furan-3-yl)-formamide (33605-73-1,87093-91-2,115630-63-2) + L-phenylalanine methyl ester (2577-90-4) → N-formylaspartame (33605-76-4) + (S)-2-Formylamino-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid (87093-92-3)

Guidance literature:

In water; at 0 - 3 ℃; Product distribution; variation of concentration, pH and solvent;

upstream raw materials:

L-Aspartic acid

Downstream raw materials:

N-formylaspartame

(S)-2-Formylamino-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid

N-(N-formyl-α-L-aspartyl)-D,L-2-chlorophenylalanine methyl ester

N-formyl-L-α-aspartyl-L-phenylalanine

Refernces