1,4-dioxopyrazinamide

Base Information

• Chemical Name: 1,4-dioxopyrazinamide
• CAS No.: 18960-19-5
• Molecular Formula: C₅H₅N₃O₃
• Molecular Weight: 155.113
• Mol file: 18960-19-5.mol

Synonyms:1,4-dioxopyrazinamide

Chemical Property of 1,4-dioxopyrazinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dioxopyrazinamide

There total 1 articles about 1,4-dioxopyrazinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrazinamide (98-96-4) → 2-pyrazinecarboxamide-4-oxide (768-36-5) + 1,4-dioxopyrazinamide (18960-19-5) + 2-Carbamyl-pyrazin-1-oxid (32046-08-5)

Guidance literature:

With dihydrogen peroxide; acetic acid; at 90 ℃; for 6h;

DOI:10.1002/ardp.200700119

Reference yield: 52.55%

1,4-dioxopyrazinamide (18960-19-5) → 3,6-dichloropyrazine-2-carbonitrile (356783-16-9)

Guidance literature:

1,4-dioxopyrazinamide; With trichlorophosphate; In chlorobenzene; at 50 - 70 ℃; for 1.83333h;

With pyridine; In chlorobenzene; at 110 ℃; for 8h; Temperature; Reagent/catalyst;

Reference yield:

1,4-dioxopyrazinamide (18960-19-5) → favipiravir (259793-96-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1.83 h / 50 - 70 °C

1.2: 6 h / 96 °C

2.1: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 55 °C / Sealed tube

3.1: dihydrogen peroxide / 2 h / 27 °C

4.1: sodium hydrogencarbonate; water / 8.5 h / 50 °C

With potassium fluoride; tetrabutylammomium bromide; water; dihydrogen peroxide; sodium hydrogencarbonate; trichlorophosphate; In dimethyl sulfoxide;

upstream raw materials:

pyrazinamide

Downstream raw materials:

3,6-difluoropyrazine-2-carbonitrile

3,6-difluoropyrazine-2-carboxamide

favipiravir

3,6-dichloropyrazine-2-carbonitrile

Refernces