768-36-5

Basic information

• Product Name: 3-pyrazinecarboxaMide 1-oxide
• Synonyms: 3-CarbaMoylpyrazine 1-oxide
• CAS NO: 768-36-5
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.1121
• Mol File: 768-36-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 597.5 °C at 760 mmHg
• Flash Point: 315.1 °C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 3.07E-14mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 3-pyrazinecarboxaMide 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-pyrazinecarboxaMide 1-oxide(768-36-5)
• EPA Substance Registry System: 3-pyrazinecarboxaMide 1-oxide(768-36-5)

Safety Data

• Hazardous Substances Data: 768-36-5(Hazardous Substances Data)

Usage

General Description

3-Pyrazinecarboxamide 1-oxide is a chemical compound classified under the category of pyrazines, which are aromatic and heterocyclic compounds. Pyrazines are characterized by their structure, which contains two nitrogen and four carbon atoms. The specific compound 3-Pyrazinecarboxamide 1-oxide is often used in medical and scientific research, however, details about its specific uses or properties are not extensively documented. As with any chemical substance, handling of 3-Pyrazinecarboxamide 1-oxide should be done with caution, observing all safety measures.

InChI:InChI=1/C5H5N3O2/c6-5(9)4-3-8(10)2-1-7-4/h1-3H,(H2,6,9)

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 
• 98-96-4 pyrazinamide 

Downstream Products

• 6863-77-0 3-aminopyrazine 1-oxide 
• 19847-12-2 2-pyrazine carbonitrile 
• 6863-74-7 6-chloropyrazine-2-carbonitrile 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 
• 55557-52-3 2-chloro-3-cyanopyrazine 
• 25594-31-4 3-pyrazinecarbonitrile N-oxide 
• 21279-64-1 5-chloro-pyrazine-2-carboxylic acid amide 
• 770-00-3 methylester of pyrazinecarboxylic acid 4-oxide 
• 132274-85-2 5-Cyano-3-phenylsulfanyl-pyrazine-2-carboxylic acid amide 
• 132274-84-1 3-Benzylsulfanyl-5-cyano-pyrazine-2-carboxylic acid amide 
• 36070-79-8 6-chloro-pyarzine-2-carboxamide 
• 1187221-99-3 C-(6-methoxypyrazin-2-yl)methylamine 
• 1187222-00-9 tert-butyl ((6-chloropyrazin-2-yl)methyl)carbamate 
• 1187222-02-1 N-(6-methoxypyrazin-2-ylmethyl)-4-phenoxybenzenesulfonamide 

Relevant articles and documents

SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES

The present invention relates to the use of pyrazinylmethyl sulfonamides of formula (I) wherein Ra, n, R1, R2, R3, A, Y and D are as defined in the claims, and the N-oxides, and salts thereof for combating harmf

Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions

We report the discovery of thiabendazole as a potent inhibitor (K 1 = 0.4 μM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range, Elucidation of the X-ray structure of ecMetAP in complex with thiabendazole and an unrelated inhibitor that was independently described by another group showed that that both compounds bind to an additional CoII ion at the entrance of the active site. This unexpected finding explains the inactivity of the compounds under in vivo conditions. It also allows us to discuss the structure-activity relationships of this series of compounds in a meaningful way, based upon docking runs with an auxiliary metal ion, We describe a new scoring function for the evaluation of metal-mediated inhibitor binding that, unlike the previously used scoring function implemented in the docking program, allows us to distinguish between active and inactive compounds, Finally, conclusions for the structure-based design of in vivo-active inhibitors of ecMetAP are drawn.

Synthesis of 2-(D-Arabino-tetrahydroxybutyl)pyrazine-5-sulfonic acid

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