25594-31-4

Basic information

• Product Name: 3-Cyanopyrazine 1-oxide
• Synonyms: 3-Cyanopyrazine 1-oxide;4-oxidopyrazin-4-ium-2-carbonitrile
• CAS NO: 25594-31-4
• Molecular Formula: C₅H₃N₃O
• Molecular Weight: 121.09682
• Mol File: 25594-31-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Cyanopyrazine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyanopyrazine 1-oxide(25594-31-4)
• EPA Substance Registry System: 3-Cyanopyrazine 1-oxide(25594-31-4)

Safety Data

• Hazardous Substances Data: 25594-31-4(Hazardous Substances Data)

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 
• 768-36-5 2-pyrazinecarboxamide-4-oxide 

Downstream Products

• 19847-12-2 2-pyrazine carbonitrile 
• 6863-74-7 6-chloropyrazine-2-carbonitrile 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 
• 55557-52-3 2-chloro-3-cyanopyrazine 
• 31722-48-2 2,5-dicyanopyrazine 

Relevant articles and documents

Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers

Treatment of electron deficient pyridine N-oxides with 4-nitrobenzoyl chloride and a cyclic thioether in the presence of triethylamine leads to the corresponding 2-functionalized product in up to a 74% isolated yield. The transformation can also be accomplished with alternative nitrogen containing heterocycles, including quinolines, pyrimidines, and pyrazines. To expand the scope of the transformation, diisopropyl ether can be used as the reaction medium to allow for the use of solid thioether substrates.