4-Methoxyquinoline

Base Information

• Chemical Name: 4-Methoxyquinoline
• CAS No.: 607-31-8
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 607-31-8.mol

Synonyms:4-Methoxy-quinoline;Quinoline, 4-methoxy-;4-Methoxychinolin;

Chemical Property of 4-Methoxyquinoline

Chemical Property:

• Vapor Pressure: 0.0444mmHg at 25°C
• Melting Point: 41°C
• Refractive Index: 1.61
• Boiling Point: 245.7 °C at 760 mmHg
• PKA: 6.37±0.13(Predicted)
• Flash Point: 89.7 °C
• PSA: 22.12000
• Density: 1.13 g/cm³
• LogP: 2.24340
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxyquinoline is used as a reactant in the synthesis of hybrid quinoline-4-yloxadiazoles/oxathiadiazoles as potent antifungal agents.

Technology Process of 4-Methoxyquinoline

There total 27 articles about 4-Methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloroquinoline (611-35-8) + sodium methylate (124-41-4) → 4-methoxyquinoline (607-31-8)

Guidance literature:

In methanol; at 70 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.8b00145

Reference yield: 97.0%

7-chloro-4-methoxyquinoline (26707-52-8) → 4-methoxyquinoline (607-31-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; lithium carbonate; In ethanol; at 23 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol403631k

Reference yield: 90.0%

4-methoxyquinoline-2-carboxylic acid (15733-83-2) → 4-methoxyquinoline (607-31-8)

Guidance literature:

With copper; In 1-methyl-pyrrolidin-2-one; at 250 ℃; for 0.833333h;

DOI:10.1021/ol1026848

upstream raw materials:

methanol

4-chloroquinoline

sodium methylate

4-nitroquinoline

Downstream raw materials:

1-methyl-4-quinolone

C₁₁H₁₂NO⁽¹⁺⁾*C₂H₆O₄P^(1-)

1-ethyl-1,4-dihydroquinolin-4-one

phenyl-quinolin-4-yl-acetonitrile

Refernces

• 1、 Nasiri, Hamid Reza,Bolte, Michael,Schwalbe, Harald. "Tautomerism of 4-hydroxy-4(1H) quinolon". . p. 319 - 322. Retrieved 2006.
• 2、 Li, Shuai,Wang, Xia,Wang, Xue-Qiang,Yang, Xin-Ge,Yu, Gui-Quan. "Deuterated Aryl Alkyl Ethers Synthesis via Nucleophilic Etherification of Aryl Alkyl Ethers and Thioethers with Deuterated Alcohols". supporting information. p. 1805 - 1809. Retrieved 2019/09/09.
• 3、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 1257; 1258. . Retrieved 2018/07/05.