7-Chloro-4-methoxyquinoline

Base Information

• Chemical Name: 7-Chloro-4-methoxyquinoline
• CAS No.: 26707-52-8
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• European Community (EC) Number: 694-516-9
• DSSTox Substance ID: DTXSID60363668
• Nikkaji Number: J3.579.965F
• Wikidata: Q82147414
• Mol file: 26707-52-8.mol

Synonyms:7-chloro-4-methoxyquinoline;26707-52-8;4-methoxy-7-chloro-quinoline;SCHEMBL1702115;SCHEMBL12891756;Quinoline, 7-chloro-4-methoxy-;DTXSID60363668;HMS1606J04;7-chloro-4-quinolinyl methyl ether;STK736084;AKOS003396095;CCG-327862;MB01887;CS-0530875;J3.579.965F;F86858;EN300-8092514;AO-080/43378153;Z31131402

Chemical Property of 7-Chloro-4-methoxyquinoline

Chemical Property:

• Melting Point: 137-138 °C
• Boiling Point: 282.2±20.0 °C(Predicted)
• PKA: 4.79±0.27(Predicted)
• PSA: 22.12000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 2.89680
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 193.0294416
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

99%, ^*data from raw suppliers

7-Chloro-4-methoxyquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2C=CC(=CC2=NC=C1)Cl

Technology Process of 7-Chloro-4-methoxyquinoline

There total 12 articles about 7-Chloro-4-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + sodium methylate (124-41-4) → 7-chloro-4-methoxyquinoline (26707-52-8)

Guidance literature:

In methanol; for 24h; Heating;

DOI:10.1021/ol702595d

Reference yield: 97.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) → 7-chloro-4-methoxyquinoline (26707-52-8)

Guidance literature:

With sodium methylate; In methanol; at 95 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c4ob01088d

Reference yield: 95.0%

methanol (67-56-1) + 4,7-dichloroquinoline (86-98-6,1138471-54-1) → 7-chloro-4-methoxyquinoline (26707-52-8)

Guidance literature:

With sodium methylate; Heating;

DOI:10.1007/s00706-015-1570-0

upstream raw materials:

7-chloro-4-hydroxylquinoline

dimethyl sulfate

methanol

4,7-dichloroquinoline

Downstream raw materials:

4-methoxyquinoline

7-(1-Adamantyl)-7,8-dihydro-4-methoxychinolin

6-(1-Adamantyl)-5,6-dihydro-4-methoxychinolin

2-(1-Adamantyl)-4-methoxychinolin

Refernces

• 1、 Tsukanov, Sergey V.,Marks, Lucas R.,Comins, Daniel L.. "Studies toward the Synthesis of Lepadiformine A". . p. 10433 - 10443. Retrieved 2016.
• 2、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 1255; 1256. . Retrieved 2018/07/05.