1-Morpholino-2,2-diphenylethanone

Base Information

• Chemical Name: 1-Morpholino-2,2-diphenylethanone
• CAS No.: 14135-68-3
• Molecular Formula: C18H19 N O2
• Molecular Weight: 281.349
• NSC Number: 54953,22795
• DSSTox Substance ID: DTXSID80281734
• Nikkaji Number: J3.325.550K
• Wikidata: Q82015789
• ChEMBL ID: CHEMBL1898267
• Mol file: 14135-68-3.mol

Synonyms:14135-68-3;1-Morpholino-2,2-diphenylethanone;1-morpholino-2,2-diphenylethan-1-one;1-morpholin-4-yl-2,2-diphenylethanone;1-(morpholin-4-yl)-2,2-diphenylethan-1-one;Ethanone, 1-(4-morpholinyl)-2,2-diphenyl-;1-Morpholin-4-yl-2,2-diphenyl-ethanone;NSC54953;N-diphenylacetylmorpholine;ChemDiv2_002203;Cambridge id 5244509;Oprea1_366371;Oprea1_689223;CBDivE_007244;MLS000104875;CHEMBL1898267;SCHEMBL11727976;DTXSID80281734;HMS1375E03;HMS2320K07;NSC22795;NSC-22795;NSC-54953;STK386929;AKOS000592581;MS-9493;SMR000054807;1-(morpholin-4-yl)-2,2-diphenylethanone;CS-0320947;EU-0084258

Chemical Property of 1-Morpholino-2,2-diphenylethanone

Chemical Property:

• Vapor Pressure: 4.65E-09mmHg at 25°C
• Boiling Point: 471.5°Cat760mmHg
• Flash Point: 238.9°C
• Density: 1.151g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 281.141578849
• Heavy Atom Count: 21
• Complexity: 308

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Morpholino-2,2-diphenylethanone

There total 7 articles about 1-Morpholino-2,2-diphenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 2,2-diphenylacetic acid (117-34-0) → 1-morpholino-2,2-diphenylethanone (14135-68-3)

Guidance literature:

2,2-diphenylacetic acid; With ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In ethyl acetate; at 21 ℃; for 2h; Inert atmosphere;

morpholine; In ethyl acetate; at 21 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201300289

Reference yield: 95.0%

1-Morpholin-4-yl-2,2-diphenyl-ethanone oxime (81838-55-3) → 1-morpholino-2,2-diphenylethanone (14135-68-3)

Guidance literature:

With cis-nitrous acid;

Reference yield: 70.0%

iodobenzene (591-50-4) + N-acetylmorpholine sodium enolate → N-(phenylacetyl)morpholine (17123-83-0) + 1-morpholino-2,2-diphenylethanone (14135-68-3)

Guidance literature:

With iron(II) sulfate; In ammonia; for 0.75h; Yields of byproduct given;

upstream raw materials:

morpholine

2,2-diphenylacetic acid

4-acetylmorpholine

bromobenzene

Refernces

• 1、 Leeuwen, Milko van,McKillop, Alexander. "A Study of the Ferrous Ion-initiated SRN1 Reactions of Halogenoarenes with tert-Butyl Acetate and N-Acylmorpholine Enolates". . p. 2433 - 2440. Retrieved 2007/10/02.
• 2、 Eckstein, Z.,Jelenski, P.,Kowal, J.,Rusek, D.. "A CONVENIENT PROCEDURE FOR DIPHENYLACETAMIDE DERIVATIVES PREPARATION". . p. 201 - 208. Retrieved 2007/10/02.