C₁₂H₁₁NO₂

Base Information

• Chemical Name: C₁₂H₁₁NO₂
• CAS No.: 1095130-53-2
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.225
• Mol file: 1095130-53-2.mol

Synonyms:C₁₂H₁₁NO₂

Chemical Property of C₁₂H₁₁NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₁NO₂

There total 2 articles about C₁₂H₁₁NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

2-(4-cyanophenoxy)ethyl alcohol (57928-96-8) + propargyl bromide (106-96-7) → C12H11NO2 (1095130-53-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol302826g

Reference yield:

4-cyanophenol (767-00-0) → C12H11NO2 (1095130-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: sodium hydride / tetrahydrofuran / 20 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1021/ol302826g

Reference yield: 62.1%

C12H11NO2 (1095130-53-2) → C12H15NO2 (1412334-19-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol302826g

upstream raw materials:

4-cyanophenol

2-(4-cyanophenoxy)ethyl alcohol

propargyl bromide

Downstream raw materials:

C₂₅H₃₁NO₅

C₁₂H₁₅NO₂

Refernces