2'-BROMO-5'-FLUOROACETOPHENONE

Base Information

• Chemical Name: 2'-BROMO-5'-FLUOROACETOPHENONE
• CAS No.: 1006-33-3
• Molecular Formula: C8H6 Br F O
• Molecular Weight: 217.037
• Hs Code.: 2914700090
• Mol file: 1006-33-3.mol

Synonyms:Acetophenone,2'-bromo-5'-fluoro- (7CI,8CI); 1-(2-Bromo-5-fluorophenyl)ethanone;2'-Bromo-5'-fluoroacetophenone

Chemical Property of 2'-BROMO-5'-FLUOROACETOPHENONE

Chemical Property:

• Refractive Index: 1.5525
• Boiling Point: 144℃/18mm
• Flash Point: 105.672oC
• PSA: 17.07000
• Density: 1.535±0.06 g/cm3(Predicted)
• LogP: 2.79080
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in methanol.

Purity/Quality:

98% ^*data from raw suppliers

2''-Bromo-5''-fluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2'-Bromo-5'-fluoroacetophenone is used in the synthesis of oxabicyclic compounds. It is also used in the enantioselective synthesis of chiral 3-aryl-1-indanone molecules.

Technology Process of 2'-BROMO-5'-FLUOROACETOPHENONE

There total 10 articles about 2'-BROMO-5'-FLUOROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2′-bromo-5′-fluorophenyl)ethan-1-ol (906673-56-1) → 1-(2′-bromo-5′-fluorophenyl)ethan-1-one (1006-33-3)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 0.2 ℃; for 4.5h;

Reference yield: 97.0%

2-bromo-5-fluoro-N-methoxy-N-methylbenzamide (313547-14-7) + methylmagnesium bromide (75-16-1) → 1-(2′-bromo-5′-fluorophenyl)ethan-1-one (1006-33-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201300917

Reference yield: 90.7%

C14H14BrFO5 → 1-(2′-bromo-5′-fluorophenyl)ethan-1-one (1006-33-3)

Guidance literature:

With sulfuric acid; acetic acid; In water; at 90 - 100 ℃; for 10h; Inert atmosphere;

DOI:10.1021/acs.oprd.0c00076

upstream raw materials:

2-bromo-5-fluoro-N-methoxy-N-methylbenzamide

methylmagnesium bromide

2-bromo-5-fluorobenzonitrile

methyl 3-(2-bromo-5-fluorophenyl)-3-oxopropionate

Downstream raw materials:

1-(2-bromo-5-fluorophenyl)-3-(dimethylamino)prop-2-en-1-one

Refernces

• 1、 Faggyas, Réka J.,Calder, Ewen D. D.,Wilson, Claire,Sutherland, Andrew. "One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Br?nsted Acid and Palladium Catalysis". . p. 11585 - 11593. Retrieved 2017.
• 2、 Wang, Zhixin,Li, Yang,Chen, Fan,Qian, Peng-Cheng,Cheng, Jiang. "The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes". supporting information. p. 1810 - 1813. Retrieved 2021/02/27.
• 3、 -. "6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)". Page/Page column 74. . Retrieved 2020/05/29.