Technology Process of 5-(3-amino-4-fluorophenoxy)picolinonitrile
There total 5 articles about 5-(3-amino-4-fluorophenoxy)picolinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-hydroxy-2-fluoroaniline;
With
potassium tert-butylate;
In
ISOPROPYLAMIDE;
for 0.5h;
2-Cyano-5-bromopyridine;
In
N,N-dimethyl acetamide;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid; 2-methyl-5-nitrophenol / 0.5 h / 0 °C
2.1: sodium hydroxide; water / 4 h / Reflux
3.1: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 2585.81 Torr
4.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h
4.2: 80 °C
With
2-methyl-5-nitrophenol; sulfuric acid; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; sodium hydroxide;
In
ethanol; N,N-dimethyl acetamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / -10 °C
2.1: sulfuric acid; 2-methyl-5-nitrophenol / 0.5 h / 0 °C
3.1: sodium hydroxide; water / 4 h / Reflux
4.1: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 2585.81 Torr
5.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h
5.2: 80 °C
With
2-methyl-5-nitrophenol; sulfuric acid; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; sodium hydroxide;
In
ethanol; N,N-dimethyl acetamide; water;
