L-(+)-cyclohexylglycine amide

Base Information

• Chemical Name: L-(+)-cyclohexylglycine amide
• CAS No.: 127042-98-2
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.228
• Mol file: 127042-98-2.mol

Synonyms:L-(+)-cyclohexylglycine amide

Chemical Property of L-(+)-cyclohexylglycine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of L-(+)-cyclohexylglycine amide

There total 4 articles about L-(+)-cyclohexylglycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1) → D-(-)-cyclohexylglycine amide (127042-98-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 23 ℃; for 40h; under 760 Torr;

DOI:10.1016/S0040-4039(01)93748-7

Reference yield: 47.0%

2-amino-2-cyclohexylacetonitrile (40651-95-4) → L-(+)-cyclohexylglycine amide (127042-98-2) + D-(-)-cyclohexylglycine amide (127042-98-2) + (2S)-amino(cyclohexyl)ethanoic acid (14328-51-9)

Guidance literature:

With potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; In water; at 30 ℃; for 21h; pH=7.62;

DOI:10.1021/jo0256282

Reference yield: 47.0%

2-amino-2-cyclohexylacetonitrile (40651-95-4) → L-(+)-cyclohexylglycine amide (127042-98-2) + D-(-)-cyclohexylglycine amide (127042-98-2) + (2S)-amino(cyclohexyl)ethanoic acid (14328-51-9)

Guidance literature:

With potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; In water; at 30 ℃; for 21h; pH=7.62;

DOI:10.1021/jo0256282

upstream raw materials:

2-amino-2-cyclohexylacetonitrile

(R)-phenylglycine amide

(R)-Phenylglycine methyl ester

Downstream raw materials:

3R,7R-dicyclohexyl-1,4,6-triazabicyclo<3.3.0.>oct-4-ene

(R)-1-Cyclohexyl-N¹-trityl-ethane-1,2-diamine

(R)-N²-((R)-2-Amino-2-cyclohexyl-ethyl)-1-cyclohexyl-N¹-trityl-ethane-1,2-diamine

(R)-2-Amino-2-cyclohexyl-N-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-acetamide

Refernces

• 1、 Corey, E. J.,Ohtani, Mitsuaki. "ENANTIOSPECIFIC SYNTHESIS OF A RIGID, C2 SYMMETRIC, CHIRAL GUANIDINE BY A NEW AND DIRECT METHOD". . p. 5227 - 5230. Retrieved 2007/10/02.