5,6-Dimethoxybenzimidazole

Base Information

• Chemical Name: 5,6-Dimethoxybenzimidazole
• CAS No.: 72721-02-9
• Molecular Formula: C9H10N2O2
• Molecular Weight: 178.191
• Hs Code.: 2933990090
• Mol file: 72721-02-9.mol

Synonyms:Benzimidazole,5,6-dimethoxy- (6CI,7CI);5,6-Dimethoxy-1H-benzimidazole;

Chemical Property of 5,6-Dimethoxybenzimidazole

Chemical Property:

• Melting Point: 183-189 °C
• Boiling Point: 398.6 °C at 760 mmHg
• PKA: 13.46±0.30(Predicted)
• Flash Point: 144.6 °C
• PSA: 47.14000
• Density: 1.245 g/cm³
• LogP: 1.58010

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dimethoxybenzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-Dimethoxybenzimidazole

There total 7 articles about 5,6-Dimethoxybenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + 4,5-dimethoxybenzene-1,2-diamine (27841-33-4) → 5,6-dimethoxybenzimidazole (72721-02-9)

Guidance literature:

formic acid; 4,5-dimethoxybenzene-1,2-diamine; for 1 - 2h; Heating / reflux;

With sodium hydroxide; In water; pH=8;

Reference yield:

4,5-dimethoxy-1,2-phenylenediamine hydrochloride salt (131076-14-7) → 5,6-dimethoxybenzimidazole (72721-02-9)

Guidance literature:

With formic acid; at 220 ℃; Microwave irradiation;

Reference yield:

formic acid (64-18-6) + 4,5-dimethoxy-1,2-phenylenediamine hydrochloride salt (131076-14-7) → 5,6-dimethoxybenzimidazole (72721-02-9)

Guidance literature:

at 220 ℃; Microwave;

upstream raw materials:

formic acid

1,2-diamino-4,5-dimethoxybenzene monohydrochloride

4,5-dimethoxy-1,2-phenylenediamine hydrochloride salt

4,5-dimethoxybenzene-1,2-diamine

Downstream raw materials:

5,6-Dihydroxybenzimidazole

5,6-dimethoxy-1-methylbenzimidazole

methyl 3-hydroxy-2-thiophenecarboxylate

Refernces

• 1、 Fan, Ka Wai,Peterson, Matthew B.,Ellersdorfer, Peter,Granville, Anthony M.. "Expanding the aqueous-based redox-facilitated self-polymerization chemistry of catecholamines to 5,6-dihydroxy-1H-benzimidazole and its 2-substituted derivatives". . p. 25203 - 25214. Retrieved 2016/03/22.
• 2、 -. "7-Substituted Purine Derivatives for Immunosuppression". Page/Page column 9. . Retrieved 2008/12/05.