3,5-Dibromobenzyl cyanide

Base Information

• Chemical Name: 3,5-Dibromobenzyl cyanide
• CAS No.: 188347-48-0
• Molecular Formula: C8H5 Br2 N
• Molecular Weight: 274.942
• Hs Code.: 2926909090
• Mol file: 188347-48-0.mol

Synonyms:(3,5-Dibromophenyl)acetonitrile

Chemical Property of 3,5-Dibromobenzyl cyanide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 344°Cat760mmHg
• Flash Point: 161.9°C
• PSA: 23.79000
• Density: 1.857g/cm³
• LogP: 3.27768
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-DibromobenzylCyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Dibromobenzyl cyanide

There total 9 articles about 3,5-Dibromobenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyano-(3,5-dibromophenyl)acetic acid ethyl ester → 2-(3,5-dibromophenyl)acetonitrile (188347-48-0)

Guidance literature:

With lithium chloride; In water; dimethyl sulfoxide; at 165 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.05.082

Reference yield: 81.0%

2-aminoacetonitrile hydrochloride (6011-14-9) + 3,5-dibromophenylboronic acid (117695-55-3) → 2-(3,5-dibromophenyl)acetonitrile (188347-48-0)

Guidance literature:

With sodium nitrite; In water; toluene; at 50 ℃; for 24h; Schlenk technique;

DOI:10.1002/anie.201406765

Reference yield: 80.0%

3,5-dibromobenzyl bromide (56908-88-4) + sodium cyanide (143-33-9,25596-52-5) → 2-(3,5-dibromophenyl)acetonitrile (188347-48-0)

Guidance literature:

In ethanol; water;

DOI:10.1021/jo962402o

upstream raw materials:

3,5-dibromobenzyl bromide

sodium cyanide

1,3-dibromo-5-(chloromethyl)benzene

(3,5-dibromophenyl)methanol

Downstream raw materials:

1-(3,5-dibromophenyl)cyclopropanecarbaldehyde

1,3-dibromo-5-(1-(difluoromethyl)cyclopropyl)benzene

3-bromo-5-(1-(difluoromethyl)cyclopropyl)benzaldehyde

C₁₃H₁₄BrF₂NO₂

Refernces

• 1、 Collier, Philip N.,Twin, Heather C.,Knegtel, Ronald M. A.,Boyall, Dean,Brenchley, Guy,Davis, Christopher J.,Keily, Shazia,Mak, Chau,Miller, Andrew,Pierard, Fran?oise,Settimo, Luca,Bolton, Clare M.,Chiu, Peter,Curnock, Adam,Doyle, Elisabeth,Tanner, Adam J.,Jimenez, Juan-Miguel. "Discovery of selective, orally bioavailable pyrazolopyridine inhibitors of protein kinase cθ (pkcθ) that ameliorate symptoms of experimental autoimmune encephalomyelitis". . p. 1134 - 1139. Retrieved 2019/08/27.
• 2、 Zhu, Wei,Wang, Yang,Li, Kai,Gao, Jian,Huang, Chun-Hsiang,Chen, Chun-Chi,Ko, Tzu-Ping,Zhang, Yonghui,Guo, Rey-Ting,Oldfield, Eric. "Antibacterial drug leads: DNA and enzyme multitargeting". . p. 1215 - 1227. Retrieved 2015/03/04.