2-Amino-5-methylbenzamide

Base Information

• Chemical Name: 2-Amino-5-methylbenzamide
• CAS No.: 40545-33-3
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Hs Code.: 2924299090
• European Community (EC) Number: 801-589-4
• DSSTox Substance ID: DTXSID50438112
• Wikidata: Q72439093
• Mol file: 40545-33-3.mol

Synonyms:2-Amino-5-methylbenzamide;40545-33-3;Benzamide, 2-amino-5-methyl-;5-methylanthranilamide;SCHEMBL688411;SCHEMBL24427475;DTXSID50438112;LLSGVPKOCZZLTF-UHFFFAOYSA-N;MFCD03428521;AKOS011800521;2-Amino-5-methylbenzamide, AldrichCPR;CS-W021569;SB76188;AC-16294;DS-13963;FT-0639649;EN300-253963;A825160;Z992346212;2,2,3,3,4,5,6-HEPTA-O-ACETYL-ALPHA-D-CELLOBIOSYLCHLORIDE

Chemical Property of 2-Amino-5-methylbenzamide

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 178-180°C
• Boiling Point: 265.7°C at 760 mmHg
• PKA: 15.88±0.50(Predicted)
• Flash Point: 114.5°C
• PSA: 69.11000
• Density: 1.185g/cm³
• LogP: 1.95760
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N)C(=O)N

Technology Process of 2-Amino-5-methylbenzamide

There total 14 articles about 2-Amino-5-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methyl-2-nitrobenzamide (4315-12-2) → 2-amino-5-methylbenzamide (40545-33-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

Reference yield: 93.0%

6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione (4692-99-3) → 2-amino-5-methylbenzamide (40545-33-3)

Guidance literature:

With ammonium hydroxide; for 4h; Ambient temperature;

Reference yield: 90.0%

2-amino-5-methylbenzonitrile (5925-93-9) → 2-amino-5-methylbenzamide (40545-33-3)

Guidance literature:

With water; potassium carbonate; In water; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1055/s-0035-1562792

upstream raw materials:

2-nitro-5-methylbenzonitrile

5-methyl-2-nitrobenzamide

6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

2-Amino-5-methylbenzoic acid

Downstream raw materials:

6-methyl-2-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>-4(3H)-quinazolinone

2-azido-5'-methyl-2'-carboxamidobenzanilide

2-azido-5-bromo-5'-methyl-2'-carboxamidobenzanilide

5-methyl-2-(prop-2'-enylamino)benzamide

Refernces

• 1、 Qian, Peng,Liu, Jiaojiao,Zhang, Yan,Wang, Zhiyong. "Tunable Electrosynthesis of Anthranilic Acid Derivatives via a C-C Bond Cleavage of Isatins". . p. 16008 - 16015. Retrieved 2021/07/31.
• 2、 Wang, Yu-Wei,Zheng, Lei,Jia, Feng-Cheng,Chen, Yun-Feng,Wu, An-Xin. "Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates". . p. 1497 - 1503. Retrieved 2019/02/13.