Technology Process of 5-phenyl-8-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
There total 5 articles about 5-phenyl-8-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ethyl phosphate;
In
1,2-dichloro-ethane;
for 0.5h;
Heating;
DOI:10.1021/jm00048a015
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / AlCl3 / 2 h / 60 °C
2: 100 percent / hydroxylamine hydrochloride, Et3N / methanol / 72 h / Ambient temperature
3: 66 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 0.5 h / Heating
With
aluminium trichloride; ethyl phosphate; hydroxylamine hydrochloride; triethylamine;
In
methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00048a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) p-toluenesulfonic acid, 2.) DDQ / 1.) reflux, 14 h, 2.) from 80 to 90 deg C, 1.5 h
2: KOH / 1.2 h / Ambient temperature
3: 100 percent / AlCl3 / 2 h / 60 °C
4: 100 percent / hydroxylamine hydrochloride, Et3N / methanol / 72 h / Ambient temperature
5: 66 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 0.5 h / Heating
With
potassium hydroxide; aluminium trichloride; ethyl phosphate; hydroxylamine hydrochloride; toluene-4-sulfonic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00048a015
