3-Methoxy-N,N-dimethylbenzylamine

Base Information

• Chemical Name: 3-Methoxy-N,N-dimethylbenzylamine
• CAS No.: 15184-99-3
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2922299090
• European Community (EC) Number: 623-692-1
• DSSTox Substance ID: DTXSID80338196
• Nikkaji Number: J364.625D
• Wikidata: Q82106449
• Mol file: 15184-99-3.mol

Synonyms:3-Methoxy-N,N-dimethylbenzylamine;15184-99-3;1-(3-methoxyphenyl)-N,N-dimethylmethanamine;(3-Methoxybenzyl)dimethylamine;3-Methoxy-N,N-dimethyl-Benzenemethanamine;SCHEMBL850832;DTXSID80338196;N,N-dimethyl-3-methoxybenzylamine;(3-methoxy-benzyl)-dimethyl-amine;3-methoxy-N,N-dimethyl benzylamine;MFCD00011530;AKOS003962560;3-Methoxy-N,N-dimethylbenzylamine, 98%;(3-Methoxyphenyl)-N,N-dimethylmethanamine #;CS-0447137;FT-0709254;A18236;J-008854

Chemical Property of 3-Methoxy-N,N-dimethylbenzylamine

Chemical Property:

• Vapor Pressure: 0.0885mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• Boiling Point: 105 °C13 mm Hg(lit.)
• PKA: 8.88±0.28(Predicted)
• Flash Point: 205 °F
• PSA: 12.47000
• Density: 0.984 g/mL at 25 °C(lit.)
• LogP: 1.75680
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 125

Purity/Quality:

98%min ^*data from raw suppliers

3-Methoxy-N,N-dimethylbenzylamine 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=CC(=CC=C1)OC

Technology Process of 3-Methoxy-N,N-dimethylbenzylamine

There total 17 articles about 3-Methoxy-N,N-dimethylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl amine (124-40-3) + 3-methoxy-benzaldehyde (591-31-1) → N,N-dimethyl-3-methoxybenzylamine (15184-99-3)

Guidance literature:

dimethyl amine; 3-methoxy-benzaldehyde; With titanium(IV) isopropylate; In methanol; at 20 ℃;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1.5h;

DOI:10.1080/00397910008087249

Reference yield: 94.0%

dimethyl amine (124-40-3) + m-methoxybenzyl chloride (824-98-6) → N,N-dimethyl-3-methoxybenzylamine (15184-99-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2008.08.057

Reference yield: 92.0%

methanol (67-56-1) + 3-methoxybenzonitrile (1527-89-5) → N,N-dimethyl-3-methoxybenzylamine (15184-99-3)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); potassium tert-butylate; at 140 ℃; for 24h;

DOI:10.1021/acscatal.8b00021

upstream raw materials:

formaldehyd

3-METHOXYBENZYLAMINE

dimethyl amine

1-bromomethyl-3-methoxybenzene

Downstream raw materials:

3-[(N,N-dimethylamino)methyl]phenol

3-Dimethylaminomethyl-phenol; hydrobromide

3-methoxy-benzaldehyde

7-methoxyisobenzofuran-1(3H)-one

Refernces

• 1、 Yang, Luo,Lin, Jie,Kang, Lei,Zhou, Wang,Ma, Da-You. "Lewis Acid-Catalyzed Reductive Amination of Aldehydes and Ketones with N,N-Dimethylformamide as Dimethylamino Source, Reductant and Solvent". supporting information. p. 485 - 490. Retrieved 2018/01/15.
• 2、 Augurusa, Alessandra,Mehta, Meera,Perez, Manuel,Zhu, Jiangtao,Stephan, Douglas W.. "Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation". supporting information. p. 12195 - 12198. Retrieved 2016/10/21.