2-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine

Base Information

• Chemical Name: 2-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
• CAS No.: 6038-38-6
• Molecular Formula: C41H54 O4
• Molecular Weight: 610.877
• Mol file: 6038-38-6.mol

Synonyms:Cholest-5-ene-3b,7b-diol, dibenzoate (6CI,7CI,8CI)

Chemical Property of 2-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine

Chemical Property:

• Vapor Pressure: 1.98E-07mmHg at 25°C
• Boiling Point: 437°Cat760mmHg
• Flash Point: 218.1°C
• Density: 1.325g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine

There total 5 articles about 2-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cholest-5-en-3β,7β-diol (566-27-8) + Benzoyltriazole → 3β,7β-bis-benzoyloxy-cholest-5-ene (6038-38-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 4h; Ambient temperature;

DOI:10.1021/jo00116a048

Reference yield:

7-ketocholesteryl acetate (809-51-8) → 3β,7β-bis-benzoyloxy-cholest-5-ene (6038-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium isopropylate; isopropyl alcohol / Behandeln der Reaktionsloesung mit wss. KOH bei Raumtemperatur; Reinigung ueber das Dibenzoyl-Derivat

2: pyridine

With pyridine; aluminum isopropoxide; isopropyl alcohol;

DOI:10.1002/hlca.19470300532

Reference yield:

cholesterol (57-88-5) → 3β,7β-bis-benzoyloxy-cholest-5-ene (6038-38-6)

Guidance literature:

Multi-step reaction with 2 steps

2: pyridine

With pyridine;

DOI:10.1002/hlca.19470300532

upstream raw materials:

cholest-5-en-3β,7β-diol

3β-benzoyloxy-cholest-5-en-7-one

cholesteryl benzoate

cholesterol

Downstream raw materials:

3β-benzoyloxycholesta-5,7-diene

7-dehydrocholesterol

5α-cholest-8-en-3β-ol

lathosterol

Refernces