3-Amino-2-chlorophenol

Base Information

• Chemical Name: 3-Amino-2-chlorophenol
• CAS No.: 56962-01-7
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID20343284
• Nikkaji Number: J160.865G
• Wikidata: Q72434625
• Mol file: 56962-01-7.mol

Synonyms:3-Amino-2-chlorophenol;56962-01-7;Phenol, 3-amino-2-chloro-;Phenol, aminochloro-;3-amino-2-chloro-phenol;2-Chloro-3-hydroxyaniline;salzsaures m-Aminophenol;3-Amino-2-chlorophenol #;3-azanyl-2-chloranyl-phenol;SCHEMBL1356386;DTXSID20343284;MFCD11044694;AKOS006308103;AM10031;MB09140;TS-01876;CS-0157219;FT-0652036;EN300-195771;A831263;AN-584/43422714

Chemical Property of 3-Amino-2-chlorophenol

Chemical Property:

• Vapor Pressure: 0.0118mmHg at 25°C
• Melting Point: 110-111 °C
• Refractive Index: 1.65
• Boiling Point: 253 °C at 760 mmHg
• Flash Point: 106.8 °C
• PSA: 46.25000
• Density: 1.406 g/cm³
• LogP: 2.20900
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 143.0137915
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

98%Min ^*data from raw suppliers

3-Amino-2-chlorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)O)Cl)N
• Uses: 3-Amino-2-chlorophenol is a useful reagent in preparation of phenol quinazolines as RET kinase inhibitors.

Technology Process of 3-Amino-2-chlorophenol

There total 4 articles about 3-Amino-2-chlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3-methoxyphenylamine (113206-03-4) → 2-chloro-3-aminophenol (56962-01-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 18h; Molecular sieve; Inert atmosphere;

DOI:10.1002/cmdc.201900376

Reference yield: 100.0%

→ 2-chloro-3-aminophenol (56962-01-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 18h; Molecular sieve; Inert atmosphere; Sealed tube;

Reference yield: 90.0%

2-chloro-3-nitrophenol (603-84-9) → 2-chloro-3-aminophenol (56962-01-7)

Guidance literature:

With ammonium chloride; zinc; In methanol; for 1h; Heating / reflux;

upstream raw materials:

2-chloro-3-nitrophenol

3-nitro-2,4-dichlorophenol

2-chloro-3-methoxyphenylamine

Downstream raw materials:

2,3-dichlorophenol

Refernces

• 1、 ?ileikyt?, Justina,Devereaux, Jordan,de Jong, Jelle,Schiavone, Marco,Jones, Kristen,Nilsen, Aaron,Bernardi, Paolo,Forte, Michael,Cohen, Michael S.. "Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability". . p. 1771 - 1782. Retrieved 2019/10/21.
• 2、 -. "GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF". Page 86-87. . Retrieved 2010/02/06.