Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate

Base Information

• Chemical Name: Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate
• CAS No.: 67817-59-8
• Molecular Formula: C₂₀H₂₂N₄O₄S
• Molecular Weight: 414.485
• Mol file: 67817-59-8.mol

Synonyms:Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate

Chemical Property of Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate

There total 4 articles about Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-Dimethoxy-6-<4-(2-furoyl)piperazin-1-ylthiocarbamido>benzonitrile (67817-56-5) + methyl iodide (74-88-4) → Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate (67817-59-8)

Guidance literature:

In ethyl acetate; at 60 ℃; for 20h;

DOI:10.1002/jhet.5570170436

Reference yield:

2-amino-4,5-dimethoxybenzonitrile (26961-27-3) → Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate (67817-59-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / CaCO₃ / H₂O; CH₂Cl₂ / 1) 0-5 deg C, 1 h; 2) 20 deg C, 20 h;

2: 90 percent / ethyl acetate / 20 h / 0 °C

3: 95 percent / ethyl acetate / 20 h / 60 °C

With calcium carbonate; In dichloromethane; water; ethyl acetate;

DOI:10.1002/jhet.5570170436

Reference yield:

2-isothiocyanato-4,5-dimethoxybenzonitrile (43091-89-0) → Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate (67817-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / ethyl acetate / 20 h / 0 °C

2: 95 percent / ethyl acetate / 20 h / 60 °C

In ethyl acetate;

DOI:10.1002/jhet.5570170436

upstream raw materials:

3,4-Dimethoxy-6-<4-(2-furoyl)piperazin-1-ylthiocarbamido>benzonitrile

methyl iodide

2-amino-4,5-dimethoxybenzonitrile

2-isothiocyanato-4,5-dimethoxybenzonitrile

Downstream raw materials:

prazosin hydrochloride

Refernces