6-fluoroindole-3-acetonitrile

Base Information

• Chemical Name: 6-fluoroindole-3-acetonitrile
• CAS No.: 2341-25-5
• Molecular Formula: C10H7FN2
• Molecular Weight: 174.177
• Hs Code.: 2933990090
• Mol file: 2341-25-5.mol

Synonyms:Indole-3-acetonitrile,6-fluoro- (6CI,7CI,8CI);2-(6-Fluoro-1H-indol-3-yl)acetonitrile;

Chemical Property of 6-fluoroindole-3-acetonitrile

Chemical Property:

• Refractive Index: 1.645
• Boiling Point: 377.3 °C at 760 mmHg
• Flash Point: 182 °C
• PSA: 39.58000
• Density: 1.316g/cm³
• LogP: 2.37308

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Fluoroindole-3-acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-fluoroindole-3-acetonitrile

There total 14 articles about 6-fluoroindole-3-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

potassium cyanide + 1-(6-fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine (343-93-1) → 2-(6-fluoro-1H-indol-3-yl)acetonitrile (2341-25-5)

Guidance literature:

In water; N,N-dimethyl-formamide; at 100 - 105 ℃; for 8h;

Reference yield: 75.0%

→ 2-(6-fluoro-1H-indol-3-yl)acetonitrile (2341-25-5)

Guidance literature:

With methanol; sodium tetrahydroborate; In formamide; at 20 ℃; for 1h;

In methanol; formamide; at 60 ℃; for 5h;

Reference yield:

C10H7FN2O2 → 2-(6-fluoro-1H-indol-3-yl)acetonitrile (2341-25-5)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 25 - 30 ℃; Reagent/catalyst;

upstream raw materials:

1-(6-fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine

potassium cyanide

dimethyl sulfate

sodium cyanide

Downstream raw materials:

2-(6-fluoro-1H-indol-3-yl)acetic acid

[2-(6-fluoro-1H-indol-3-yl)ethyl]({[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl})amine HCl salt

tryptamine

6-fluorotryptamine

Refernces

• 1、 Egami, Hiromichi,Hotta, Ryo,Otsubo, Minami,Rouno, Taiki,Niwa, Tomoki,Yamashita, Kenji,Hamashima, Yoshitaka. "Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst". supporting information. p. 5656 - 5660. Retrieved 2020/07/14.
• 2、 -. "PROCESS FOR THE MANUFACTURE OF IDALOPIRDINE". Paragraph 0083; 0084; 0085. . Retrieved 2016/07/05.