3-BROMO-5-FLUORO-2-METHOXYPYRIDINE

Base Information

• Chemical Name: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE
• CAS No.: 884494-81-9
• Molecular Formula: C6H5BrFNO
• Molecular Weight: 206.014
• Hs Code.: 2933399090
• Mol file: 884494-81-9.mol

Synonyms:3-BROMO-5-FLUORO-2-METHOXYPYRIDINE;3-Bromo-5-fluoro-2-methoxypyridine ,98%;Pyridine, 3-bromo-5-fluoro-2-methoxy-;3-Bromo-5-fluoropyridin-2-yl methyl ether

Chemical Property of 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE

Chemical Property:

• Vapor Pressure: 0.83mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 188.356 °C at 760 mmHg
• PKA: -1.38±0.20(Predicted)
• Flash Point: 67.715 °C
• PSA: 22.12000
• Density: 1.621 g/cm³
• LogP: 1.99180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-fluoro-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-fluoro-2-methoxypyridine is a compound used in the synthesis of 5-Fluoro-2-methoxy-3-(2R)-2-pyrrolidinylpyridine (1213093-30-1).

Technology Process of 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE

There total 4 articles about 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-fluoro-2-methoxypyridine (51173-04-7) → 3-bromo-5-fluoro-2-methoxypyridine (884494-81-9)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 70 ℃; for 5h; Temperature;

Reference yield: 43.8%

3-bromo-5-fluoropyridin-2(1H)-one (884494-94-4) + methyl iodide (74-88-4) → 3-bromo-5-fluoro-2-methoxypyridine (884494-81-9)

Guidance literature:

With silver carbonate; In toluene; at 20 ℃;

Reference yield:

2-methoxy-5-nitropyridine (5446-92-4) → 3-bromo-5-fluoro-2-methoxypyridine (884494-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 60 °C

2.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 - 20 °C

2.2: 2 h / 40 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 5 h / 70 °C

With hydrogenchloride; N-Bromosuccinimide; 5%-palladium/activated carbon; hydrogen; sodium nitrite; In tetrahydrofuran; methanol; water;

upstream raw materials:

3-bromo-5-fluoropyridin-2(1H)-one

methyl iodide

5-fluoro-2-methoxypyridine

2-methoxy-5-nitropyridine

Downstream raw materials:

(5-fluoro-2-methoxypyridin-3-yl)boronic acid

C₁₀H₁₃FN₂O*2ClH

5-fluoro-2-methoxynicotinic acid methyl ester

5-fluoro-2-methoxypyridine-3-carbaldehyde

Refernces

• 1、 -. "SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS". Page/Page column 74-75. . Retrieved 2011/02/24.