5-fluoro-2-methoxy-3-pyridineboronic acid

Base Information

• Chemical Name: 5-fluoro-2-methoxy-3-pyridineboronic acid
• CAS No.: 957120-32-0
• Molecular Formula: C6H7BFNO3
• Molecular Weight: 170.936
• Hs Code.: 2933399090
• Mol file: 957120-32-0.mol

Synonyms:(5-fluoro-2-methoxy-3-pyridyl)boronic acid;5-Fluoro-2-methoxypyridine-3-boronic acid 98%;

Chemical Property of 5-fluoro-2-methoxy-3-pyridineboronic acid

Chemical Property:

• Boiling Point: 327.6 °C at 760 mmHg
• Flash Point: 151.9 °C
• PSA: 62.58000
• Density: 1.34 g/cm³
• LogP: -1.09090
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-2-methoxypyridine-3-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-2-methoxypyridine-3-boronic acid

Technology Process of 5-fluoro-2-methoxy-3-pyridineboronic acid

There total 1 articles about 5-fluoro-2-methoxy-3-pyridineboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-bromo-5-fluoro-2-methoxypyridine (884494-81-9) + Triisopropyl borate (5419-55-6) → (5-fluoro-2-methoxypyridin-3-yl)boronic acid (957120-32-0)

Guidance literature:

3-bromo-5-fluoro-2-methoxypyridine; Triisopropyl borate; With n-butyllithium; In tetrahydrofuran; hexanes; at -100 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexanes; water; at 0 ℃; for 1h;

Reference yield: 78.4%

(5-fluoro-2-methoxypyridin-3-yl)boronic acid (957120-32-0) + 1-benzyl-4-(6-chloro-5-fluoropyridin-3-yl)piperidine-4-carbonitrile → 1-benzyl-4-{3,5'-difluoro-2'-methoxy-[2,3'-bipyridin]-5-yl}piperidine-4-carbonitrile

Guidance literature:

With methanesulfonato(2-dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl)(2’-methylamino-1,1‘-biphenyl-2-yl)palladium(II); potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield: 73.0%

(5-fluoro-2-methoxypyridin-3-yl)boronic acid (957120-32-0) + N-[4-(8-bromo-6-tert-butyl-5-methoxy-3-quinolyl)phenyl]methanesulfonamide (1257830-36-6) → N-[4-[6-tert-butyl-8-(5-fluoro-2-methoxy-3-pyridyl)-5-methoxy-3-quinolyl]phenyl]methanesulfonamide (1485748-91-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; dichloromethane; at 115 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm401329s

upstream raw materials:

3-bromo-5-fluoro-2-methoxypyridine

Triisopropyl borate

Downstream raw materials:

N-[4-[(E)-2-[3-tert-butyl-5-(5-fluoro-2-oxo-1H-pyridin-3-yl)-2-methoxyphenyl]vinyl]phenyl]methanesulfonamide

C₂₇H₂₈FN₃O₅S

4-tert-butyl-2-(5-fluoro-2-methoxy-3-pyridyl)aniline

N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

Refernces

• 1、 -. "Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors". Page/Page column 21. . Retrieved 2012/06/18.