2-Chloro-3,4-difluoroaniline

Base Information

• Chemical Name: 2-Chloro-3,4-difluoroaniline
• CAS No.: 36556-48-6
• Molecular Formula: C6H4 Cl F2 N
• Molecular Weight: 163.554
• Hs Code.: 2921420090
• DSSTox Substance ID: DTXSID60693159
• Wikidata: Q72518294
• Mol file: 36556-48-6.mol

Synonyms:2-Chloro-3,4-difluoroaniline;36556-48-6;Benzenamine, 2-chloro-3,4-difluoro-;SCHEMBL8375067;DTXSID60693159;2-Chloro-3,4-difluorobenzenamine;AMY28297;MFCD11044823;AKOS006307077;FS-4288;SB75770;CS-0137308;FT-0712069;EN300-6764233;A856668

Chemical Property of 2-Chloro-3,4-difluoroaniline

Chemical Property:

• PSA: 26.02000
• LogP: 2.78160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 163.0000331
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-3,4-difluoroaniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1N)Cl)F)F

Technology Process of 2-Chloro-3,4-difluoroaniline

There total 1 articles about 2-Chloro-3,4-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-Chloro-3,4-difluoroaniline (36556-48-6)

Guidance literature:

Nitriergemisch (Laut 19F-NMR: Hauptkomponente 2-Chlor-3,4-difluoranilin), Zinnchlorid, HCl, Reduktion;

DOI:10.1016/S0022-1139(00)82962-0

Reference yield: 99.0%

2-Chloro-3,4-difluoroaniline (36556-48-6) + 2,4-difluoro-3-chloro-aniline (2613-34-5) → 2,4-difluorophenylamine (367-25-9,76563-56-9)

Guidance literature:

With sodium hydroxide; palladium; In hydrogenchloride; methanol; water;

Reference yield: 54.1%

2-Chloro-3,4-difluoroaniline (36556-48-6) → 2-chloro-3,4-difluorobenzenesulfonic acid

Guidance literature:

2-Chloro-3,4-difluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With sulfur dioxide; acetic acid; copper dichloride; In water; at 0 ℃; for 0.25h; under 775.743 Torr;

Downstream raw materials:

2,4-difluorophenylamine