Technology Process of 2-[3-(4-Bromo-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole
There total 8 articles about 2-[3-(4-Bromo-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) CO2 as a continous stream for 1h
2: thionyl chloride
3: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h
4: triethylamine / dichloromethane / -22 °C
5: lithium bromide / N,N-dimethyl-formamide
With
sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; triethylamine; lithium bromide;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027