Cyclohexanecarboxamide, N,N-dimethyl-

Base Information

• Chemical Name: Cyclohexanecarboxamide, N,N-dimethyl-
• CAS No.: 17566-51-7
• Molecular Formula: C9H17 N O
• Molecular Weight: 155.24
• Mol file: 17566-51-7.mol

Synonyms:N,N-Dimethylcyclohexanecarboxamide

Chemical Property of Cyclohexanecarboxamide, N,N-dimethyl-

Chemical Property:

• Vapor Pressure: 0.0225mmHg at 25°C
• Boiling Point: 249.7°Cat760mmHg
• Flash Point: 104.6°C
• PSA: 20.31000
• Density: 0.961g/cm³
• LogP: 1.65490
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Dimethylcyclohexanecarboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxamide, N,N-dimethyl-

There total 12 articles about Cyclohexanecarboxamide, N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

dimethylamine borane (74-94-2) + Cyclohexanecarboxylic acid (98-89-5) → N,N-dimethylcyclohexanecarboxamide (17566-51-7)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 12h; Reflux;

DOI:10.1021/acs.orglett.0c03184

Reference yield: 91.0%

N,N-dimethylbenzamide (611-74-5) → N,N-dimethylcyclohexanecarboxamide (17566-51-7)

Guidance literature:

With tetrahydroxydiboron; [Rh(OH)(cod)]2; In ethanol; at 50 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00341

Reference yield: 91.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + Cyclohexanecarboxylic acid (98-89-5) → N,N-dimethylcyclohexanecarboxamide (17566-51-7)

Guidance literature:

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; at 120 ℃; for 6h;

DOI:10.1055/s-0035-1561427

upstream raw materials:

dimethyl amine

cyclohexanylcarbonyl chloride

N,N,N',N'-tetramethylethylendiamine

1,5-diiodopentane

Downstream raw materials:

cyclohexyl ethyl ketone

N,N-dimethylcyclohexylmethylamine

cyclohexanecarbaldehyde

(dimethyl(phenyl)silyl)(cyclohexyl)methanone

Refernces

• 1、 Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders. "Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds". . p. 4623 - 4661. Retrieved 2021/05/07.
• 2、 Baumann, Marcus,Bonciolini, Stefano,Di Filippo, Mara. "A scalable continuous photochemical process for the generation of aminopropylsulfones". supporting information. p. 9428 - 9432. Retrieved 2020/12/15.