2-Bromo-5-methylpyrazine

Base Information

• Chemical Name: 2-Bromo-5-methylpyrazine
• CAS No.: 98006-90-7
• Molecular Formula: C5H5 Br N2
• Molecular Weight: 173.012
• Hs Code.: 2933990090
• Mol file: 98006-90-7.mol

Synonyms:2-Bromo-5-methylpyrazine

Chemical Property of 2-Bromo-5-methylpyrazine

Chemical Property:

• Vapor Pressure: 0.511mmHg at 25°C
• Boiling Point: 198℃
• PKA: -0.36±0.10(Predicted)
• Flash Point: 74℃
• PSA: 25.78000
• Density: 1.596
• LogP: 1.54750

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Bromo-5-methylpyrazine is a chemical compound with applications across different fields. In the field of pharmaceuticals and medicinal chemistry, it may be employed as an intermediate for the synthesis of various pharmaceutical drugs, potentially contributing to the development of medications with therapeutic applications. In the agrochemical industry, it can find use as a building block for the creation of specialized chemicals, such as pesticides or herbicides, which play a crucial role in crop protection and agricultural practices. Additionally, in the field of organic chemistry, this compound can serve as a versatile starting material for the synthesis of complex organic molecules, aiding in the development of novel chemical compounds with diverse applications. Its adaptability as a pharmaceutical intermediate, agrochemical building block, and chemical building block underscores its significance in advancing pharmaceuticals, agriculture, and organic chemistry in various fields.

Technology Process of 2-Bromo-5-methylpyrazine

There total 4 articles about 2-Bromo-5-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

5-methylpyrazin-2-amine (5521-58-4) → 2-bromo-5-methyl-pyrazine (98006-90-7)

Guidance literature:

5-methylpyrazin-2-amine; With hydrogen bromide; In water; at 25 - 30 ℃;

With bromine; In water; at -50 ℃; for 1h;

With sodium nitrite; In water; at -50 ℃; for 1.5h;

DOI:10.1002/jhet.3479

Reference yield:

5-methylpyrazine-2-carboxylic acid methyl ester (41110-33-2) → 2-bromo-5-methyl-pyrazine (98006-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonia / methanol / 4 h / 0 - 5 °C

2.1: potassium hydroxide; bromine / water / 0 - 90 °C

3.1: hydrogen bromide / water / 25 - 30 °C

3.2: 1 h / -50 °C

3.3: 1.5 h / -50 °C

With ammonia; hydrogen bromide; bromine; potassium hydroxide; In methanol; water; 2.1: |Hofmann Rearrangement;

DOI:10.1002/jhet.3479

Reference yield:

5‐methylpyrazine-2-carboxamide (5521-57-3) → 2-bromo-5-methyl-pyrazine (98006-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide; bromine / water / 0 - 90 °C

2.1: hydrogen bromide / water / 25 - 30 °C

2.2: 1 h / -50 °C

2.3: 1.5 h / -50 °C

With hydrogen bromide; bromine; potassium hydroxide; In water; 1.1: |Hofmann Rearrangement;

DOI:10.1002/jhet.3479

upstream raw materials:

5-methylpyrazine-2-carboxylic acid methyl ester

5‐methylpyrazine-2-carboxamide

5-methylpyrazin-2-amine

2-methylpyrazin-5-carboxylic acid

Downstream raw materials:

2-isopropoxy-5-methylpyrazine

2-Methyl-5-vinyl-pyrazine

t-Butyl 2-(5-methylpyrazin-2-yl]-1H-pyrrole-1-carboxylate

1-(5-methyl-pyrazin-2-yl)-piperidin-4-ol

Refernces