5-Methylpyrazine-2-carboxamide

Base Information

• Chemical Name: 5-Methylpyrazine-2-carboxamide
• CAS No.: 5521-57-3
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.141
• Hs Code.: 2934999090
• European Community (EC) Number: 673-815-8
• DSSTox Substance ID: DTXSID40374999
• Nikkaji Number: J195.980H
• Wikidata: Q72496248
• Mol file: 5521-57-3.mol

Synonyms:5-methylpyrazine-2-carboxamide;5521-57-3;5-Methyl-pyrazine-2-carboxamide;pyrazinecarboxamide, 5-methyl-;2-carbamoyl-5-methylpyrazine;MFCD00190581;5-Methyl-2-pyrazinamide;5-Methyl-2-pyrazinecarboxamide;SCHEMBL147506;AMY5213;DTXSID40374999;OYBQCUZBVHFPBU-UHFFFAOYSA-N;AKOS008937704;AS-43116;SY106637;A7992;BB 0220610;CS-0152780;FT-0620617;EN300-115992;J-517822

Chemical Property of 5-Methylpyrazine-2-carboxamide

Chemical Property:

• Melting Point: 212 °C
• Boiling Point: 307.7 °C at 760 mmHg
• PKA: 14.12±0.50(Predicted)
• Flash Point: 139.9 °C
• PSA: 68.87000
• Density: 1.237 g/cm³
• LogP: 0.58420
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.058911855
• Heavy Atom Count: 10
• Complexity: 137

Purity/Quality:

99% ^*data from raw suppliers

5-methylpyrazine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=N1)C(=O)N

Technology Process of 5-Methylpyrazine-2-carboxamide

There total 7 articles about 5-Methylpyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-methylpyrazine-2-carboxylic acid methyl ester (41110-33-2) → 5‐methylpyrazine-2-carboxamide (5521-57-3)

Guidance literature:

With ammonia; In methanol; at 0 - 5 ℃; for 4h;

DOI:10.1002/jhet.3479

Reference yield: 32.0%

2,5-dimethyl-pyrazine (123-32-0) → 1,4-pyrazine (290-37-9) + pyrazinamide (98-96-4) + 5‐methylpyrazine-2-carboxamide (5521-57-3) + 2,5-pyrazinedicarboxamide (41110-27-4)

Guidance literature:

With ammonium hydroxide; air; antimony(III) trioxide; titanium(IV) oxide; molybdenum(VI) oxide; at 400 ℃;

DOI:10.1007/BF02508713

Reference yield:

5-methylpyrazine-2-carbonitrile (98006-91-8) → 5‐methylpyrazine-2-carboxamide (5521-57-3)

Guidance literature:

With sodium hydroxide monohydrate; dihydrogen peroxide; In water; at 55 - 60 ℃; for 1h; pH=8 - 9;

upstream raw materials:

2-methylpyrazin-5-carboxylic acid

2,5-dimethyl-pyrazine

5-methylpyrazine-2-carboxylic acid methyl ester

3-carboxamido-2-hydroxy-6-methylpyrazine

Downstream raw materials:

5-methylpyrazin-2-amine

2-bromo-5-methyl-pyrazine

acipimox

Refernces

• 1、 KomReddy, Venugopal,Rillema, D. Paul,Nguyen, Huy,Kadel, Lava. "Synthesis and Characterization of 2-(2-Pyridinyl)pyrazine and 2,2′-Bipyrazine Derivatives". . p. 972 - 979. Retrieved 2019/02/05.