Technology Process of ND0118
There total 9 articles about ND0118 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(4-methylpiperazin-1-ylmethyl)benzoic acid;
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
5-((5-amino-2-methylbenzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1021/acs.jmedchem.6b00087
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
acetic acid;
In
dichloromethane;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / Reflux; Inert atmosphere
2: lithium hydroxide; water / tetrahydrofuran / 4 h / Reflux
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C
With
water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
![5-((5-amino-2-methylbenzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
