(S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Base Information

• Chemical Name: (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt
• CAS No.: 1460202-50-9
• Molecular Formula: C₅H₁₂N₂*C₁₅H₁₄O₅
• Molecular Weight: 374.437
• Mol file: 1460202-50-9.mol

Synonyms:(S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Chemical Property of (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

There total 6 articles about (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(-)-3-aminopiperidine hydrochloride (334618-23-4) + 3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (1460202-45-2) → (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt (1460202-50-9) + (R)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; at 55 - 65 ℃; for 1h; Overall yield = 0.51 g;

Reference yield:

3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (1460202-45-2) + (S)-piperidin-3-amine (54012-73-6,80918-66-7,127294-73-9,128441-15-6) → (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt (1460202-50-9) + (R)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Guidance literature:

In isopropyl alcohol; at 20 - 65 ℃; Overall yield = 0.51 g;

Reference yield:

4-hydroxyphenylacetate (156-38-7) → (S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt (1460202-50-9) + (R)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 40 h / 115 - 120 °C

2.1: lithium hydroxide; water / N,N-dimethyl-formamide / 60 - 70 °C

3.1: methanol; palladium on activated charcoal; hydrogen / N,N-dimethyl-formamide / 60 - 65 °C / 6000.6 - 7500.75 Torr

3.2: 20 °C

4.1: isopropyl alcohol / 20 - 65 °C

With methanol; palladium on activated charcoal; water; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid

(S)-piperidin-3-amine

4-hydroxyphenylacetate

2,4-Dihydroxybenzaldehyde

Downstream raw materials:

(S)-4-(3-hydroxy-2-(4-hydroxyphenyl)propyl)benzene-1,3-diol

equol

Refernces

• 1、 -. "IMPROVED PROCESS FOR PRODUCING (S)-EQUOL". Page/Page column 21. . Retrieved 2013/10/21.