Piperidin-3-amine

Base Information

• Chemical Name: Piperidin-3-amine
• CAS No.: 54012-73-6
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.164
• Hs Code.: 2933399090
• European Community (EC) Number: 611-081-2
• DSSTox Substance ID: DTXSID90276414
• Nikkaji Number: J2.137.631K
• Mol file: 54012-73-6.mol

Synonyms:piperidin-3-amine

Chemical Property of Piperidin-3-amine

Chemical Property:

• Vapor Pressure: 2.69mmHg at 25°C
• Melting Point: 55-57°C
• Boiling Point: 168-170°C
• PKA: 10.49±0.20(Predicted)
• Flash Point: 52.7°C
• PSA: 38.05000
• Density: 0.91g/cm³
• LogP: 0.72620
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 100.100048391
• Heavy Atom Count: 7
• Complexity: 54

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminopiperidine ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-36/37/39-45-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)N
• Uses: 3-Aminopiperidine is a useful reactant or the synthesis of cationic amphiphilic compounds.

Technology Process of Piperidin-3-amine

There total 14 articles about Piperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(3S)-3-aminopiperidin-2-one hydrochloride (42538-31-8,406216-02-2) → (S)-piperidin-3-amine (54012-73-6,80918-66-7,127294-73-9,128441-15-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 15.25h; Inert atmosphere; Reflux;

DOI:10.3987/COM-17-13683

Reference yield: 52.0%

→ (S)-piperidin-3-amine (54012-73-6,80918-66-7,127294-73-9,128441-15-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -80 - 90 ℃; for 10h;

Reference yield:

pyridin-3-ylamine (462-08-8) → 3-aminopiperidine (54012-73-6,80918-66-7,127294-73-9,128441-15-6) + 1,2,3,6-tetrahydropyridine (694-05-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; water; for 0.15h; Ambient temperature;

DOI:10.3987/COM-93-6476

upstream raw materials:

pyridin-3-ylamine

pyridine-2,5-diamine

ethanol

3-nitropyridine

Downstream raw materials:

3-(phthalimido)piperidine

(R)-piperidin-3-ylamine

(S)-piperidin-3-amine

3-(R)-aminopiperidine dihydrochloride

Refernces

• 1、 -. "Substituted xanthine compound and its preparation and use (by machine translation)". Paragraph 0213; 0214; 0217; 0218. . Retrieved 2018/09/26.
• 2、 Sakurai, Rumiko,Sakai, Kenichi,Kodama, Koichi,Yamaura, Masanori. "Dielectrically controlled resolution (DCR) of 3-aminopiperidine via diastereomeric salt formation with N-tosyl-(S)-phenylalanine". . p. 221 - 224. Retrieved 2012/06/15.