2,4-Difluoropyridine

Base Information

• Chemical Name: 2,4-Difluoropyridine
• CAS No.: 34941-90-7
• Molecular Formula: C5H3F2N
• Molecular Weight: 115.082
• Hs Code.: 2933399090
• European Community (EC) Number: 680-722-6
• DSSTox Substance ID: DTXSID00376499
• Nikkaji Number: J2.134.034K
• Wikidata: Q72464168
• Mol file: 34941-90-7.mol

Synonyms:2,4-difluoropyridine;34941-90-7;Pyridine, 2,4-difluoro-;MFCD04114162;2,4-Difluoro-pyridine;2,4-bis(fluoranyl)pyridine;SCHEMBL1697620;DTXSID00376499;WLAKUAILRGATSL-UHFFFAOYSA-N;AC-340;BBL100923;STL554717;AKOS005063485;CS-W011239;PB26122;SY024692;TS-01588;AM20061755;FT-0600158;EN300-99859;(DECAHYDRO-NAPHTHALEN-1-YL)-ACETICACID;A822471;J-507221

Chemical Property of 2,4-Difluoropyridine

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 16.8mmHg at 25°C
• Refractive Index: 1.446
• Boiling Point: 122.4 °C at 760 mmHg
• PKA: -1.55±0.10(Predicted)
• Flash Point: 27.8 °C
• PSA: 12.89000
• Density: 1.263 g/cm³
• LogP: 1.35980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 115.02335542
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1F)F
• Uses: 2,4-Difluoropyridine

Technology Process of 2,4-Difluoropyridine

There total 13 articles about 2,4-Difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-chloro-2,4-difluoropyridine (851179-01-6) → 2,4-difluoropyridine (34941-90-7)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In octanol; at 75 ℃; for 4h;

DOI:10.1002/chem.200400837

Reference yield: 51.0%

2,4-difluoro-6-hydrazinopyridine (837364-98-4) → 2,4-difluoropyridine (34941-90-7)

Guidance literature:

With copper(II) sulfate; In water; for 0.416667h; Heating;

DOI:10.1021/jo047962z

Reference yield:

2,4,6-trifluoropyridine (3512-17-2) → 2-fluoropyridine (372-48-5) + 2,4-difluoropyridine (34941-90-7)

Guidance literature:

With hydrogen; In methanol; water; at 20 - 180 ℃; for 3h; Autoclave;

upstream raw materials:

pyridine

2,4-difluoro-6-hydrazinopyridine

3-chloro-2,4-difluoropyridine

2,4,6-trifluoro-3-(triethylsilyl)pyridine

Downstream raw materials:

2-fluoropyridin-4-ol

2-hydroxy-4-fluoropyridine

Refernces

• 1、 Zámostná, Lada,Ahrens, Mike,Braun, Thomas. "Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates". . p. 132 - 142. Retrieved 2013/10/01.
• 2、 Schlosser, Manfred,Rausis, Thierry,Bobbio, Carla. "Rerouting nucleophilic substitution from the 4-position to the 2- or 6-position of 2,4-dihalopyridines and 2,4,6-trihalopyridines: The solution to a long-standing problem". . p. 127 - 129. Retrieved 2007/10/03.